Anti-Granzyme B antibody [SRP15089] (STJ11109819)

SKU:
STJ11109819
£110.50 - £505.50
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Applications:WB/ELISA
Host:Rabbit
Reactivity:Mouse
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality :Polyclonal
Clone ID :SRP15089
Isotype:IgG
Conjugation:Unconjugated
Purification:Affinity purification
Dilution Range:WB, 1:1000-1:3000
ELISA, Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. For high-ratio antibody dilutions (≥1:10000) , a sequential dilution method is strongly recomme
Storage Instruction:Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol:Gzmb
Gene ID:14939
Uniprot ID:GRAB_MOUSE
Immunogen:Synthetic peptide. This information is considered to be commercially sensitive.
Function Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent pyroptosis when delivered into the target cell through the immunological synapse. It cleaves after Asp. Once delivered into the target cell, acts by catalyzing cleavage of gasdermin-E (GSDME), releasing the pore-forming moiety of GSDME, thereby triggering pyroptosis and target cell death. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3 and -9 (CASP3 and CASP9, respectively) to give rise to active enzymes mediating apoptosis. Cleaves and activates CASP7 in response to bacterial infection, promoting plasma membrane repair.
Protein Name Granzyme B(G -H
Ctla-1
Cytotoxic Cell Protease 1
Ccp1
Fragmentin-2
Database Links Reactome: R-MMU-5620971
Reactome: -MMU-75108
Cellular Localisation Secreted
Cytolytic Granule
Delivered Into The Target Cell By Perforin
Alternative Antibody Names Anti-Granzyme B(G -H antibody
Anti-Ctla-1 antibody
Anti-Cytotoxic Cell Protease 1 antibody
Anti-Ccp1 antibody
Anti-Fragmentin-2 antibody
Anti-Gzmb antibody
Anti-Ctla-1 antibody
Anti-Ctla1 antibody

Information sourced from Uniprot.org

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