| Function | Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent pyroptosis when delivered into the target cell through the immunological synapse. It cleaves after Asp. Once delivered into the target cell, acts by catalyzing cleavage of gasdermin-E (GSDME), releasing the pore-forming moiety of GSDME, thereby triggering pyroptosis and target cell death. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3 and -9 (CASP3 and CASP9, respectively) to give rise to active enzymes mediating apoptosis. Cleaves and activates CASP7 in response to bacterial infection, promoting plasma membrane repair. |
| Protein Name | Granzyme B(G -HCtla-1Cytotoxic Cell Protease 1Ccp1Fragmentin-2 |
| Database Links | Reactome: R-MMU-5620971Reactome: -MMU-75108 |
| Cellular Localisation | SecretedCytolytic GranuleDelivered Into The Target Cell By Perforin |
| Alternative Antibody Names | Anti-Granzyme B(G -H antibodyAnti-Ctla-1 antibodyAnti-Cytotoxic Cell Protease 1 antibodyAnti-Ccp1 antibodyAnti-Fragmentin-2 antibodyAnti-Gzmb antibodyAnti-Ctla-1 antibodyAnti-Ctla1 antibody |
Information sourced from Uniprot.org
![Anti-Granzyme B antibody [11F1] (STJ16101744)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/600x533/products/152250/347100/STJ16101744_1__56495.1681999365.jpg?c=1 "Anti-Granzyme B antibody [11F1] (STJ16101744)")