| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Monoclonal |
| Clone ID: |
S4817RM |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:1000-1:5000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
GPX1 |
| Gene ID: |
2876 |
| Uniprot ID: |
GPX1_HUMAN |
| Immunogen Region: |
100-203 |
| Specificity: |
A synthetic peptide corresponding to a sequence within amino acids 100-203 of human GPX1 (NP_000572.2). |
| Immunogen Sequence: |
RPGGGFEPNFMLFEKCEVNG AGAHPLFAFLREALPAPSDD ATALMTDPKLITWSPVCRND VAWNFEKFLVGPDGVPLRRY SRRFQTIDIEPDIEALLSQG PSCA |
| Tissue Specificity | Expressed in platelets (at protein level). |
| Post Translational Modifications | During periods of oxidative stress, Sec-49 may react with a superoxide radical, irreversibly lose hydroselenide and be converted to dehydroalanine. |
| Function | Catalyzes the reduction of hydroperoxides in a glutathione-dependent manner thus regulating cellular redox homeostasis. Can reduce small soluble hydroperoxides such as H2O2, cumene hydroperoxide and tert-butyl hydroperoxide, as well as several fatty acid-derived hydroperoxides. In platelets catalyzes the reduction of 12-hydroperoxyeicosatetraenoic acid, the primary product of the arachidonate 12-lipoxygenase pathway. |
| Protein Name | Glutathione Peroxidase 1Gpx-1Gshpx-1Cellular Glutathione PeroxidasePhospholipid-Hydroperoxide Glutathione Peroxidase Gpx1 |
| Database Links | Reactome: R-HSA-2142688Reactome: R-HSA-2142712Reactome: R-HSA-2142770Reactome: R-HSA-3299685 |
| Cellular Localisation | CytoplasmMitochondrion |
| Alternative Antibody Names | Anti-Glutathione Peroxidase 1 antibodyAnti-Gpx-1 antibodyAnti-Gshpx-1 antibodyAnti-Cellular Glutathione Peroxidase antibodyAnti-Phospholipid-Hydroperoxide Glutathione Peroxidase Gpx1 antibodyAnti-GPX1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
