| Tissue Specificity | Ubiquitously expressed. |
| Function | Plays an important role in mitotic spindle pole organization via its interaction with NUMA1. Required for cortical dynein-dynactin complex recruitment during metaphase. Plays a role in metaphase spindle orientation. Also plays an important role in asymmetric cell divisions. Has guanine nucleotide dissociation inhibitor (GDI) activity towards G(i) alpha proteins, such as GNAI1 and GNAI3, and thereby regulates their activity. |
| Protein Name | G-Protein-Signaling Modulator 2Mosaic Protein Lgn |
| Database Links | Reactome: R-HSA-418594 |
| Cellular Localisation | CytoplasmCell CortexCytoskeletonSpindle PoleLateral Cell MembraneLocalizes In The Cytoplasm During Interphase And At Cell Cortex During MetaphaseColocalizes With Numa1 To Mitotic Spindle PolesLocalized At The Central And Lateral Cell Cortex Regions In A Rangtp-Dependent MannerIn Horizontally Retinal Progenitor Dividing CellsLocalized To The Lateral Cortical RegionIn Vertically Retinal Progenitor Dividing CellsLocalized At The Polar Cortical Region |
| Alternative Antibody Names | Anti-G-Protein-Signaling Modulator 2 antibodyAnti-Mosaic Protein Lgn antibodyAnti-GPSM2 antibodyAnti-LGN antibody |
Information sourced from Uniprot.org
