• Western blot analysis of various lysates using GPSM2 Rabbit polyclonal antibody (STJ112571) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 10s.

Anti-GPSM2 antibody (380-490) (STJ112571)

SKU:
STJ112571

£112.50 - £522.50
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Host: Rabbit
Applications: WB
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-GPSM2 (380-490) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:1000-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: GPSM2
Gene ID: 29899
Uniprot ID: GPSM2_HUMAN
Immunogen Region: 380-490
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 380-490 of human GPSM2 (NP_037428.3).
Immunogen Sequence: STNNSIMSENTEIDSSLNGV RPKLGRRHSMENMELMKLTP EKVQNWNSEILAKQKPLIAK PSAKLLFVNRLKGKKYKTNS STKVLQDASNSIDHRIPNSQ RKISADTIGDE
Tissue Specificity Ubiquitously expressed.
Function Plays an important role in mitotic spindle pole organization via its interaction with NUMA1. Required for cortical dynein-dynactin complex recruitment during metaphase. Plays a role in metaphase spindle orientation. Also plays an important role in asymmetric cell divisions. Has guanine nucleotide dissociation inhibitor (GDI) activity towards G(i) alpha proteins, such as GNAI1 and GNAI3, and thereby regulates their activity.
Protein Name G-Protein-Signaling Modulator 2
Mosaic Protein Lgn
Database Links Reactome: R-HSA-418594
Cellular Localisation Cytoplasm
Cell Cortex
Cytoskeleton
Spindle Pole
Lateral Cell Membrane
Localizes In The Cytoplasm During Interphase And At Cell Cortex During Metaphase
Colocalizes With Numa1 To Mitotic Spindle Poles
Localized At The Central And Lateral Cell Cortex Regions In A Rangtp-Dependent Manner
In Horizontally Retinal Progenitor Dividing Cells
Localized To The Lateral Cortical Region
In Vertically Retinal Progenitor Dividing Cells
Localized At The Polar Cortical Region
Alternative Antibody Names Anti-G-Protein-Signaling Modulator 2 antibody
Anti-Mosaic Protein Lgn antibody
Anti-GPSM2 antibody
Anti-LGN antibody

Information sourced from Uniprot.org

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