| Tissue Specificity | Expressed at low levels in adult tissues. |
| Post Translational Modifications | Autoproteolytically cleaved into 2 subunits, an extracellular alpha subunit and a seven-transmembrane subunit. |
| Function | G-protein coupled receptor which has an essential role in the development of hearing and vision. Couples to G-alpha(i)-proteins, GNAI1/2/3, G-alpha(q)-proteins, GNAQ, as well as G-alpha(s)-proteins, GNAS, inhibiting adenylate cyclase (AC) activity and cAMP production. Required for the hair bundle ankle formation, which connects growing stereocilia in developing cochlear hair cells of the inner ear. In response to extracellular calcium, activates kinases PKA and PKC to regulate myelination by inhibiting the ubiquitination of MAG, thus enhancing the stability of this protein in myelin-forming cells of the auditory pathway. In retina photoreceptors, the USH2 complex is required for the maintenance of periciliary membrane complex that seems to play a role in regulating intracellular protein transport. Involved in the regulation of bone metabolism. ADGRV1 subunit beta: Cleaved ADGRV1 beta-subunit couples with G-alpha(i)-proteins, GNAI1/2/3, and constitutively inhibits adenylate cyclase (AC) activity with a stronger effect than full ADGRV1. |
| Protein Name | Adhesion G-Protein Coupled Receptor V1Adgrv1G-Protein Coupled Receptor 98Monogenic Audiogenic Seizure Susceptibility Protein 1 HomologUsher Syndrome Type-2c ProteinVery Large G-Protein Coupled Receptor 1 Cleaved Into - Adgrv1 Subunit Alpha - Adgrv1 Subunit Beta |
| Database Links | Reactome: R-HSA-9619665 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinCell ProjectionStereocilium MembranePhotoreceptor Inner SegmentLocalizes At The Ankle Region Of The StereociliaIn PhotoreceptorsLocalizes At A Plasma Membrane Microdomain In The Apical Inner Segment That Surrounds The Connecting Cilia Called Periciliary Membrane Complex |
| Alternative Antibody Names | Anti-Adhesion G-Protein Coupled Receptor V1 antibodyAnti-Adgrv1 antibodyAnti-G-Protein Coupled Receptor 98 antibodyAnti-Monogenic Audiogenic Seizure Susceptibility Protein 1 Homolog antibodyAnti-Usher Syndrome Type-2c Protein antibodyAnti-Very Large G-Protein Coupled Receptor 1 Cleaved Into - Adgrv1 Subunit Alpha - Adgrv1 Subunit Beta antibodyAnti-ADGRV1 antibodyAnti-GPR98 antibodyAnti-KIAA0686 antibodyAnti-KIAA1943 antibodyAnti-MASS1 antibodyAnti-VLGR1 antibody |
Information sourced from Uniprot.org
