| Function | Orphan G protein-coupled receptor implicated in a large repertoire of behavioral responses that engage motor activities, spatial learning, and emotional processing. May play a role in the regulation of cognitive and motor function. Couples with the heterotrimeric G protein complex of the G(i) subfamily, consisting of GNAI1, GNB1 and GNG2, thereby acting through a G(i)-mediated pathway. Plays a role in the attenuation of D1 dopamine receptor (D1R)-mediated cAMP response in ciliated cells. In non-ciliated cells, involved in the inhibition of the beta-2 adrenergic receptor (B2AR) response. |
| Protein Name | G Protein-Coupled Receptor 88Striatum-Specific G-Protein Coupled Receptor |
| Database Links | |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinCell ProjectionCilium MembraneCytoplasmNucleusLocalized To Cilia In Ciliated CellsWhereas In Non-Ciliated CellsDistributed Throughout The Cell MembraneDuring Cortical LaminationSubcellular Location ShiftsOn The Day Of BirthFrom Expression At The Plasma Membrane And In The Cytoplasm To The Nuclei Of NeuronsThis Intranuclear Localization Remains Throughout Adulthood |
| Alternative Antibody Names | Anti-G Protein-Coupled Receptor 88 antibodyAnti-Striatum-Specific G-Protein Coupled Receptor antibodyAnti-GPR88 antibodyAnti-STRG antibody |
Information sourced from Uniprot.org
