| Function | Proton-sensing G-protein coupled receptor activated by extracellular pH, which is required to monitor pH changes and generate adaptive reactions. Activated by an optimal pH of 7.4. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. GPR65 is mainly coupled to G(s) G proteins and mediates activation of adenylate cyclase activity. May also act as a receptor for the glycosphingolipid psychosine (PSY) and several related glycosphingolipids. Plays a role in immune response by maintaining lysosome function and regulating T-cell metabolism. Acts as a regulator of inflammation by mediating pH-sensing of extracellular acidification which takes place in inflamed tissues: activation regulates endo-lysosomal function of immune cells and T-cell metabolism. Constitutively active in endosomes and stimulates adenylate cyclase production from endosomes independently from extracellular pH changes. |
| Protein Name | G-Protein Coupled Receptor 65Psychosine ReceptorT-Cell Death-Associated Gene 8 Protein |
| Database Links | Reactome: R-HSA-373076Reactome: R-HSA-416476 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinEarly Endosome MembraneLate Endosome MembraneInternalizes And Localizes To Early And Late EndosomesFrom Where Gpr65 Signals At Steady StateIrrespective Of Extracellular PhChanges In Extracellular Ph May Relocalize Receptor Signaling To The Cell Membrane |
| Alternative Antibody Names | Anti-G-Protein Coupled Receptor 65 antibodyAnti-Psychosine Receptor antibodyAnti-T-Cell Death-Associated Gene 8 Protein antibodyAnti-GPR65 antibodyAnti-TDAG8 antibody |
Information sourced from Uniprot.org
