Anti-GPR50 antibody (301-350 aa) (STJ93389)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human MTR1L at the amino acid range 301-350
General Information
| Short Description | Rabbit polyclonal anti-Melatonin-related receptor (301-350 aa) for use in WB, IF and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IF 1:200-1:1000ELISA 1:10000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | GPR50 |
| Gene ID | 9248 |
| Uniprot ID | MTR1L_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human MTR1L at the amino acid range 301-350 |
| Immunogen Region | 301-350 aa |
| Specificity | GPR50 Polyclonal Antibody detects endogenous levels of GPR50 protein. |
Additional Info
| Post Translational Modifications | Cleaved by CAPN1 in a calcium-dependent manner. |
| Function | G protein-coupled receptor that plays a role in numerous physiological processes including regulation of energy metabolism, neurite outgrowth or cell migration. Promotes self-renewal and neuronal differentiation of neural progenitor cells through activation of the NOTCH and WNT/beta-catenin signaling pathways. Modulates the KAT5-dependent glucocorticoid receptor signaling by modulating KAT5 subcellular compartmentalisation. Also plays a role in the activation TGFBR1 in the absence of TGFBR2 by interfering with FKBP1A binding to TGFBR1, leading to induction of both canonical and non-canonical SMAD signaling pathways resulting in inhibition of proliferation or promotion of migration. C-terminal domain: Upon cleavage by CAPN1, functions as a scaffold in the nucleus for interacting partners such as GTF2I to promote FOS promoter activation. |
| Protein Name | Melatonin-Related ReceptorG Protein-Coupled Receptor 50H9 Cleaved Into - C-Terminal Domain |
| Database Links | |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinPostsynaptic DensityC-Terminal Domain: Nucleus |
| Alternative Antibody Names | Anti-Melatonin-Related Receptor antibodyAnti-G Protein-Coupled Receptor 50 antibodyAnti-H9 Cleaved Into - C-Terminal Domain antibodyAnti-GPR50 antibody |
Information sourced from Uniprot.org