• Immunohistochemistry analysis of paraffin-embedded human brain tissue, using ETBR2 Antibody. The picture on the right is blocked with the synthesized peptide.
  • Western blot analysis of lysates from HepG2 cells, using ETBR2 Antibody. The lane on the right is blocked with the synthesized peptide.
  • Immunofluorescence analysis of LOVO cells, using ETBR2 Antibody. The picture on the right is blocked with the synthesized peptide.

Anti-GPR37L1 antibody (1-50 aa) (STJ93382)

SKU:
STJ93382

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: WB/IHC/IF/ELISA
Reactivity: Human/Rat/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-G-protein coupled receptor 37-like 1 (1-50 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IHC 1:100-1:300
IF 1:200-1:1000
ELISA 1:10000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: GPR37L1
Gene ID: 9283
Uniprot ID: G37L1_HUMAN
Immunogen Region: 1-50 aa
Specificity: GPR37L1 Polyclonal Antibody detects endogenous levels of GPR37L1 protein.
Immunogen: The antiserum was produced against synthesized peptide derived from the human ETBR2 at the amino acid range 1-50
Post Translational Modifications O-glycosylated. Undergoes metalloprotease-mediated cleavage which reduces its constitutive activity. Ubiquitinated.
Function G-protein coupled receptor. Has been shown to bind the neuroprotective and glioprotective factor prosaposin (PSAP), leading to endocytosis followed by an ERK phosphorylation cascade. However, other studies have shown that prosaposin does not increase activity. It has been suggested that GPR37L1 is a constitutively active receptor which signals through the guanine nucleotide-binding protein G(s) subunit alpha. Participates in the regulation of postnatal cerebellar development by modulating the Shh pathway. Regulates baseline blood pressure in females and protects against cardiovascular stress in males. Mediates inhibition of astrocyte glutamate transporters and reduction in neuronal N-methyl-D-aspartate receptor activity.
Protein Name G-Protein Coupled Receptor 37-Like 1
Endothelin B Receptor-Like Protein 2
Etbr-Lp-2
Database Links Reactome: R-HSA-375276
Reactome: R-HSA-418594
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Cell Projection
Cilium Membrane
Associates With The Basal Membrane Of Bergmann Glia Cell Primary Cilia
Alternative Antibody Names Anti-G-Protein Coupled Receptor 37-Like 1 antibody
Anti-Endothelin B Receptor-Like Protein 2 antibody
Anti-Etbr-Lp-2 antibody
Anti-GPR37L1 antibody
Anti-ETBRLP2 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance