| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-GPR37 (40-180) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
GPR37 |
| Gene ID: |
2861 |
| Uniprot ID: |
GPR37_HUMAN |
| Immunogen Region: |
40-180 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 40-180 of human GPR37 (NP_005293.1). |
| Immunogen Sequence: |
LGESCAPTVIQRRGRDAWGP GNSARDVLRARAPREEQGAA FLAGPSWDLPAAPGRDPAAG RGAEASAAGPPGPPTRPPGP WRWKGARGQEPSETLGRGNP TALQLFLQISEEEEKGPRGA GISGRSQEQSVKTVPGASDL F |
| Tissue Specificity | Expressed in brain and spinal cord, and at lower levels in testis, placenta and liver, but no detectable expression observed in any other tissue. When overexpressed in cells, tends to become insoluble and unfolded. Accumulation of the unfolded protein may lead to dopaminergic neuronal death in juvenile Parkinson disease (PDJ). |
| Post Translational Modifications | Ubiquitinated by PRKN in the presence of UBE2E1 and UBE2L3 in the endoplasmic reticulum. The unfolded form is specifically ubiquitinated by SYVN1, which promotes its proteasomal degradation and prevents neuronal cell death. |
| Function | Receptor for the neuroprotective and glioprotective factor prosaposin. Ligand binding induces endocytosis, followed by an ERK phosphorylation cascade. |
| Protein Name | Prosaposin Receptor Gpr37Endothelin B Receptor-Like Protein 1Etbr-Lp-1G-Protein Coupled Receptor 37Parkin-Associated Endothelin Receptor-Like ReceptorPaelr |
| Database Links | Reactome: R-HSA-375276Reactome: R-HSA-418594 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinEndoplasmic Reticulum Membrane |
| Alternative Antibody Names | Anti-Prosaposin Receptor Gpr37 antibodyAnti-Endothelin B Receptor-Like Protein 1 antibodyAnti-Etbr-Lp-1 antibodyAnti-G-Protein Coupled Receptor 37 antibodyAnti-Parkin-Associated Endothelin Receptor-Like Receptor antibodyAnti-Paelr antibodyAnti-GPR37 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
