| Short Description : | Rabbit polyclonal anti-Probable G-protein coupled receptor 34 (181-230 aa) for use in WB, IF and ELISA in Human, Mouse, Rat and Monkey samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/IF/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat/Monkey |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | 1 mg/mL |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range: | WB 1:500-1:2000IF 1:200-1:1000ELISA 1:10000 |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | GPR34 |
| Gene ID: | 2857 |
| Uniprot ID: | GPR34_HUMAN |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human GPR34 at the amino acid range 181-230 |
| Immunogen Region: | 181-230 aa |
| Specificity: | GPR34 Polyclonal Antibody detects endogenous levels of GPR34 protein. |
| Function | G-protein-coupled receptor of lysophosphatidylserine (LysoPS) that plays different roles in immune response. Acts a damage-sensing receptor that triggers tissue repair upon recognition of dying neutrophils. Mechanistically, apoptotic neutrophils release lysophosphatydilserine that are recognized by type 3 innate lymphoid cells (ILC3s) via GPR34, which activates downstream PI3K-AKT and RAS-ERK signaling pathways leading to STAT3 activation and IL-22 production. Plays an important role in microglial function, controlling morphology and phagocytosis. |
| Protein Name | Probable G-Protein Coupled Receptor 34 |
| Database Links | |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Probable G-Protein Coupled Receptor 34 antibodyAnti-GPR34 antibody |
Information sourced from Uniprot.org
