| Host: |
Rabbit |
| Applications: |
IHC/IF |
| Reactivity: |
Human/Rat/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Probable G-protein coupled receptor 179 is suitable for use in Immunohistochemistry and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
IHC-P 1:50-300IF 1:50-200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
GPR179 |
| Gene ID: |
440435 |
| Uniprot ID: |
GP179_HUMAN |
| Specificity: |
GP179 Polyclonal Antibody detects endogenous levels of protein. |
| Immunogen: |
Synthesized peptide derived from part of the human protein |
| Function | Orphan receptor involved in vision. Required for signal transduction through retinal depolarizing bipolar cells. Acts as an atypical G-protein coupled receptor that recruits and regulates the R7 group RGS-GNB5 complexes instead of activating G proteins: promotes the GTPase activator activity of R7 RGS proteins, increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Associates with components of metabotropic signaling cascade in retina ON-bipolar neurons, such as TRPM1 and GRM6: may control the ability of the GRM6 cascade to gate TRPM1. |
| Protein Name | Probable G-Protein Coupled Receptor 179Probable G-Protein Coupled Receptor 158-Like 1Gpr158-Like |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinPostsynaptic Cell MembraneCell ProjectionDendriteSpecifically Localizes To The Tips Of Retinal On-Bipolar Dendrites |
| Alternative Antibody Names | Anti-Probable G-Protein Coupled Receptor 179 antibodyAnti-Probable G-Protein Coupled Receptor 158-Like 1 antibodyAnti-Gpr158-Like antibodyAnti-GPR179 antibodyAnti-GPR158L antibodyAnti-GPR158L1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
