Anti-GPR179 antibody (STJ192655)

SKU:
STJ192655

Current Stock:
Host: Rabbit
Applications: IHC/IF
Reactivity: Human/Rat/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Probable G-protein coupled receptor 179 is suitable for use in Immunohistochemistry and Immunofluorescence research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: IHC-P 1:50-300
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: GPR179
Gene ID: 440435
Uniprot ID: GP179_HUMAN
Specificity: GP179 Polyclonal Antibody detects endogenous levels of protein.
Immunogen: Synthesized peptide derived from part of the human protein
Function Orphan receptor involved in vision. Required for signal transduction through retinal depolarizing bipolar cells. Acts as an atypical G-protein coupled receptor that recruits and regulates the R7 group RGS-GNB5 complexes instead of activating G proteins: promotes the GTPase activator activity of R7 RGS proteins, increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. Associates with components of metabotropic signaling cascade in retina ON-bipolar neurons, such as TRPM1 and GRM6: may control the ability of the GRM6 cascade to gate TRPM1.
Protein Name Probable G-Protein Coupled Receptor 179
Probable G-Protein Coupled Receptor 158-Like 1
Gpr158-Like
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Postsynaptic Cell Membrane
Cell Projection
Dendrite
Specifically Localizes To The Tips Of Retinal On-Bipolar Dendrites
Alternative Antibody Names Anti-Probable G-Protein Coupled Receptor 179 antibody
Anti-Probable G-Protein Coupled Receptor 158-Like 1 antibody
Anti-Gpr158-Like antibody
Anti-GPR179 antibody
Anti-GPR158L antibody
Anti-GPR158L1 antibody

Information sourced from Uniprot.org

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