Anti-GP6/GPVI antibody {ABflo® 647} (STJ11108593)

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STJ11108593
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Host: Rabbit
Applications: FC
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality : Monoclonal
Conjugation: ABflo® 647
Isotype: IgG
Formulation: PBS containing 0.2% BSA, preserved with proclin300 or sodium azide (as specified on the Certificate of Analysis) , pH 7.3.
Purification: Affinity purification
Dilution Range: FC, 5 Mu l per 10^6 cells in 100 Mu l volume
Storage Instruction: Store at 4°C for up to 1 year from the date of receipt. Do not freeze.
Gene Symbol: GP6
Gene ID: 51206
Uniprot ID: GPVI_HUMAN
Immunogen: Recombinant protein (or fragment).This information is considered to be commercially sensitive.
Tissue Specificity Megakaryocytes and platelets.
Post Translational Modifications N-linked glycosylation at Asn-92 is not required for the cell surface expression, but contributes to maximal adhesion to type I collagen, collagen-related peptide (CRP), and, to a lesser extent, to the snake venom C-type lectin convulxin (CVX).
Function Collagen receptor involved in collagen-induced platelet adhesion and activation. Plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR gamma-chain, the Src kinases (likely FYN or LYN) and SYK, the adapter protein LAT and leads to the activation of PLCG2.
Protein Name Platelet Glycoprotein Vi
Gpvi
Glycoprotein 6
Database Links Reactome: R-HSA-114604
Reactome: R-HSA-202733
Reactome: R-HSA-75892
Cellular Localisation Isoform 1: Cell Membrane
Single-Pass Membrane Protein
Isoform 2: Cell Membrane
Alternative Antibody Names Anti-Platelet Glycoprotein Vi antibody
Anti-Gpvi antibody
Anti-Glycoprotein 6 antibody
Anti-GP6 antibody

Information sourced from Uniprot.org

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