| Host: | Rabbit |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | GP1BA |
| Gene ID: | 2811 |
| Uniprot ID: | GP1BA_HUMAN |
| Immunogen Region: | 19-259 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 19-259 of human CD42b (NP_000164.5). |
| Immunogen Sequence: | ICEVSKVASHLEVNCDKRNL TALPPDLPKDTTILHLSENL LYTFSLATLMPYTRLTQLNL DRCELTKLQVDGTLPVLGTL DLSHNQLQSLPLLGQTLPAL TVLDVSFNRLTSLPLGALRG LGELQELYLKGNELKTLPPG LLTPTPKLEKLSLANNNLTE LPAGLLNGLENLDTLLLQEN SLYTIPKGFFGSHLLPFAFL HGNPWLCNCEILYFRRWLQD NAENVYVWKQGVDVKAMTS |
| Post Translational Modifications | Glycocalicin is the product of a proteolytic cleavage/shedding, catalyzed by ADAM17, which releases most of the extracellular domain. Binding sites for vWF and thrombin are in this part of the protein. |
| Function | GP-Ib, a surface membrane protein of platelets, participates in the formation of platelet plugs by binding to the A1 domain of vWF, which is already bound to the subendothelium. |
| Protein Name | Platelet Glycoprotein Ib Alpha ChainGp-Ib AlphaGpib-AlphaGpibaGlycoprotein IbalphaAntigen Cd42b-AlphaCd Antigen Cd42b Cleaved Into - Glycocalicin |
| Database Links | Reactome: R-HSA-140837Reactome: R-HSA-430116Reactome: R-HSA-75892Reactome: R-HSA-76009Reactome: R-HSA-8936459Reactome: R-HSA-9673221Reactome: R-HSA-9845620Reactome: R-HSA-9846298 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Platelet Glycoprotein Ib Alpha Chain antibodyAnti-Gp-Ib Alpha antibodyAnti-Gpib-Alpha antibodyAnti-Gpiba antibodyAnti-Glycoprotein Ibalpha antibodyAnti-Antigen Cd42b-Alpha antibodyAnti-Cd Antigen Cd42b Cleaved Into - Glycocalicin antibodyAnti-GP1BA antibody |
Information sourced from Uniprot.org
