| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-GORASP2 (353-452) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
GORASP2 |
| Gene ID: |
26003 |
| Uniprot ID: |
GORS2_HUMAN |
| Immunogen Region: |
353-452 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 353-452 of human GORASP2 (NP_056345.3). |
| Immunogen Sequence: |
PGIAPLPLPSEFLPSFPLVP ESSSAASSGELLSSLPPTSN APSDPATTTAKADAASSLTV DVTPPTAKAPTTVEDRVGDS TPVSEKPVSAAVDANASESP |
| Post Translational Modifications | Myristoylated. Myristoylation is essential for the Golgi targeting. Palmitoylated. Phosphorylated in mitotic cells. ER stress-induced phosphorylation at Ser-441 induces monomerization and subsequent relocalization from Golgi to ER which is essential for mediating unconventional (ER/Golgi-independent) trafficking of CFTR to the cell membrane. |
| Function | Key structural protein of the Golgi apparatus. The membrane cisternae of the Golgi apparatus adhere to each other to form stacks, which are aligned side by side to form the Golgi ribbon. Acting in concert with GORASP1/GRASP65, is required for the formation and maintenance of the Golgi ribbon, and may be dispensable for the formation of stacks. However, other studies suggest that GORASP2 plays a role in the assembly and membrane stacking of the Golgi cisternae, and in the process by which Golgi stacks reform after breakdown during mitosis and meiosis. May regulate the intracellular transport and presentation of a defined set of transmembrane proteins, such as transmembrane TGFA. Required for normal acrosome formation during spermiogenesis and normal male fertility, probably by promoting colocalization of JAM2 and JAM3 at contact sites between germ cells and Sertoli cells. Mediates ER stress-induced unconventional (ER/Golgi-independent) trafficking of core-glycosylated CFTR to cell membrane. |
| Protein Name | Golgi Reassembly-Stacking Protein 2Grs2Golgi Phosphoprotein 6Golph6Golgi Reassembly-Stacking Protein Of 55 KdaGrasp55P59 |
| Database Links | Reactome: R-HSA-162658 |
| Cellular Localisation | Golgi Apparatus MembraneLipid-AnchorEndoplasmic Reticulum MembraneGolgi ApparatusDetected In The Intermediate GolgiMembrane-AssociatedEr Stress Triggers Its Relocalization From Golgi To Er Membrane |
| Alternative Antibody Names | Anti-Golgi Reassembly-Stacking Protein 2 antibodyAnti-Grs2 antibodyAnti-Golgi Phosphoprotein 6 antibodyAnti-Golph6 antibodyAnti-Golgi Reassembly-Stacking Protein Of 55 Kda antibodyAnti-Grasp55 antibodyAnti-P59 antibodyAnti-GORASP2 antibodyAnti-GOLPH6 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
