| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-GNPDA2 (1-190) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:200-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
GNPDA2 |
| Gene ID: |
132789 |
| Uniprot ID: |
GNPI2_HUMAN |
| Immunogen Region: |
1-190 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-190 of human GNPDA2 (NP_612208.1). |
| Immunogen Sequence: |
MRLVILDNYDLASEWAAKYI CNRIIQFKPGQDRYFTLGLP TGSTPLGCYKKLIEYHKNGH LSFKYVKTFNMDEYVGLPRN HPESYHSYMWNNFFKHIDID PNNAHILDGNAADLQAECDA FENKIKEAGGIDLFVGGIGP DGHIAFNEPGSSLVSRTRLK TLAMDTILANAKYFDGDLSK VPTMALTVGV |
| Tissue Specificity | Ubiquitous, with highest expression detected in testis, ovary, placenta, and heart. |
| Function | Catalyzes the reversible conversion of alpha-D-glucosamine 6-phosphate (GlcN-6P) into beta-D-fructose 6-phosphate (Fru-6P) and ammonium ion, a regulatory reaction step in de novo uridine diphosphate-N-acetyl-alpha-D-glucosamine (UDP-GlcNAc) biosynthesis via hexosamine pathway. Deamination is coupled to aldo-keto isomerization mediating the metabolic flux from UDP-GlcNAc toward Fru-6P. At high ammonium level can drive amination and isomerization of Fru-6P toward hexosamines and UDP-GlcNAc synthesis. Has a role in fine tuning the metabolic fluctuations of cytosolic UDP-GlcNAc and their effects on hyaluronan synthesis that occur during tissue remodeling. |
| Protein Name | Glucosamine-6-Phosphate Isomerase 2Glucosamine-6-Phosphate Deaminase 2Gnpda 2Glcn6p Deaminase 2Glucosamine-6-Phosphate Isomerase Sb52 |
| Database Links | Reactome: R-HSA-70171 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Glucosamine-6-Phosphate Isomerase 2 antibodyAnti-Glucosamine-6-Phosphate Deaminase 2 antibodyAnti-Gnpda 2 antibodyAnti-Glcn6p Deaminase 2 antibodyAnti-Glucosamine-6-Phosphate Isomerase Sb52 antibodyAnti-GNPDA2 antibodyAnti-GNP2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
![Western blot analysis of lysates from wild type (WT) and ATF2 knockout (KO) 293T cells, using [KO Validated] ATF2 Rabbit polyclonal antibody (STJ22702) at 1:500 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/300x300/products/99177/383848/STJ22702_1__38112.1713152438.jpg?c=1 "Western blot analysis of lysates from wild type (WT) and ATF2 knockout (KO) 293T cells, using [KO Validated] ATF2 Rabbit polyclonal antibody (STJ22702) at 1:500 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s.")