| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | GNMT |
| Gene ID: | 27232 |
| Uniprot ID: | GNMT_HUMAN |
| Immunogen Region: | 1-295 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-295 of human GNMT (NP_061833.1). |
| Immunogen Sequence: | MVDSVYRTRSLGVAAEGLPD QYADGEAARVWQLYIGDTRS RTAEYKAWLLGLLRQHGCQR VLDVACGTGVDSIMLVEEGF SVTSVDASDKMLKYALKERW NRRHEPAFDKWVIEEANWMT LDKDVPQSAEGGFDAVICLG NSFAHLPDCKGDQSEHRLAL KNIASMVRAGGLLVIDHRNY DHILSTGCAPPGKNIYYKSD LTKDVTTSVLIVNNKAHMVT LDYTVQVPGAGQDGSPGLS |
| Tissue Specificity | Expressed only in liver, pancreas, and prostate. |
| Function | Catalyzes the methylation of glycine by using S-adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy), a reaction regulated by the binding of 5-methyltetrahydrofolate. Plays an important role in the regulation of methyl group metabolism by regulating the ratio between S-adenosyl-L-methionine and S-adenosyl-L-homocysteine. |
| Protein Name | Glycine N-Methyltransferase |
| Database Links | Reactome: R-HSA-2408508Reactome: R-HSA-389661 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Glycine N-Methyltransferase antibodyAnti-GNMT antibody |
Information sourced from Uniprot.org
