| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | GNB5 |
| Gene ID: | 10681 |
| Uniprot ID: | GNB5_HUMAN |
| Immunogen Region: | 1-200 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human GNB5 (NP_006569.1). |
| Immunogen Sequence: | MATEGLHENETLASLKSEAE SLKGKLEEERAKLHDVELHQ VAERVEALGQFVMKTRRTLK GHGNKVLCMDWCKDKRRIVS SSQDGKVIVWDSFTTNKEHA VTMPCTWVMACAYAPSGCAI ACGGLDNKCSVYPLTFDKNE NMAAKKKSVAMHTNYLSACS FTNSDMQILTASGDGTCALW DVESGQLLQSFHGHGADVLC |
| Tissue Specificity | Widely expressed. |
| Function | Enhances GTPase-activating protein (GAP) activity of regulator of G protein signaling (RGS) proteins, such as RGS7 and RGS9, hence involved in the termination of the signaling initiated by the G protein coupled receptors (GPCRs) by accelerating the GTP hydrolysis on the G-alpha subunits, thereby promoting their inactivation. Increases RGS7 GTPase-activating protein (GAP) activity, thereby regulating mood and cognition. Increases RGS9 GTPase-activating protein (GAP) activity, hence contributes to the deactivation of G protein signaling initiated by D(2) dopamine receptors. May play an important role in neuronal signaling, including in the parasympathetic, but not sympathetic, control of heart rate. |
| Protein Name | Guanine Nucleotide-Binding Protein Subunit Beta-5Gbeta5Transducin Beta Chain 5 |
| Database Links | Reactome: R-HSA-1296041Reactome: R-HSA-202040Reactome: R-HSA-2514859 O14775-1Reactome: R-HSA-381676Reactome: R-HSA-392170Reactome: R-HSA-392451Reactome: R-HSA-392851Reactome: R-HSA-400042Reactome: R-HSA-4086398Reactome: R-HSA-416476Reactome: R-HSA-416482Reactome: R-HSA-418217Reactome: R-HSA-418555Reactome: R-HSA-418592Reactome: R-HSA-418594Reactome: R-HSA-418597Reactome: R-HSA-420092Reactome: R-HSA-428930Reactome: R-HSA-432040Reactome: R-HSA-456926Reactome: R-HSA-500657Reactome: R-HSA-6814122Reactome: R-HSA-8964315Reactome: R-HSA-8964616Reactome: R-HSA-9009391Reactome: R-HSA-9634597Reactome: R-HSA-9660821Reactome: R-HSA-997272 |
| Cellular Localisation | Membrane |
| Alternative Antibody Names | Anti-Guanine Nucleotide-Binding Protein Subunit Beta-5 antibodyAnti-Gbeta5 antibodyAnti-Transducin Beta Chain 5 antibodyAnti-GNB5 antibody |
Information sourced from Uniprot.org
