| Host: | Rabbit |
| Applications: | WB/IHC-P/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IHC-P:1:50-1:200IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | GNB2 |
| Gene ID: | 2783 |
| Uniprot ID: | GBB2_HUMAN |
| Immunogen Region: | 1-340 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-340 of human GNB2 (NP_005264.2). |
| Immunogen Sequence: | MSELEQLRQEAEQLRNQIRD ARKACGDSTLTQITAGLDPV GRIQMRTRRTLRGHLAKIYA MHWGTDSRLLVSASQDGKLI IWDSYTTNKVHAIPLRSSWV MTCAYAPSGNFVACGGLDNI CSIYSLKTREGNVRVSRELP GHTGYLSCCRFLDDNQIITS SGDTTCALWDIETGQQTVGF AGHSGDVMSLSLAPDGRTFV SGACDASIKLWDVRDSMCRQ TFIGHESDINAVAFFPNGY |
| Tissue Specificity | Expressed in all cardiac subcompartments and in the brain, with highest levels in the atrioventricular node and brain. |
| Function | Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. |
| Protein Name | Guanine Nucleotide-Binding Protein G(I/G(S/G(T Subunit Beta-2G Protein Subunit Beta-2Transducin Beta Chain 2 |
| Database Links | Reactome: R-HSA-1296041Reactome: R-HSA-163359Reactome: R-HSA-202040Reactome: R-HSA-381676Reactome: R-HSA-392170Reactome: R-HSA-392451Reactome: R-HSA-392851Reactome: R-HSA-400042Reactome: R-HSA-4086398Reactome: R-HSA-416476Reactome: R-HSA-416482Reactome: R-HSA-418217Reactome: R-HSA-418555Reactome: R-HSA-418592Reactome: R-HSA-418594Reactome: R-HSA-418597Reactome: R-HSA-420092Reactome: R-HSA-428930Reactome: R-HSA-432040Reactome: R-HSA-456926Reactome: R-HSA-500657Reactome: R-HSA-6814122Reactome: R-HSA-8964315Reactome: R-HSA-8964616Reactome: R-HSA-9009391Reactome: R-HSA-9634597Reactome: R-HSA-9660821Reactome: R-HSA-997272 |
| Cellular Localisation | CytoplasmPerinuclear RegionCell Membrane |
| Alternative Antibody Names | Anti-Guanine Nucleotide-Binding Protein G(I/G(S/G(T Subunit Beta-2 antibodyAnti-G Protein Subunit Beta-2 antibodyAnti-Transducin Beta Chain 2 antibodyAnti-GNB2 antibody |
Information sourced from Uniprot.org