| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Guanine nucleotide-binding protein Gi subunit alpha-2 (274-324 aa) is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | GNAI2 |
| Gene ID: | 2771 |
| Uniprot ID: | GNAI2_HUMAN |
| Immunogen Region: | 274-324 aa |
| Specificity: | This antibody detects endogenous levels of GNAI2 at Human/Mouse/Rat |
| Immunogen: | Synthesized peptide derived from the human GNAI2 at the amino acid range 274-324 |
| Function | Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. May play a role in cell division. Isoform sGi2: Regulates the cell surface density of dopamine receptors DRD2 by sequestrating them as an intracellular pool. |
| Protein Name | Guanine Nucleotide-Binding Protein G(I Subunit Alpha-2Adenylate Cyclase-Inhibiting G Alpha Protein |
| Database Links | Reactome: R-HSA-170670Reactome: R-HSA-392170Reactome: R-HSA-400042Reactome: R-HSA-418555Reactome: R-HSA-418594Reactome: R-HSA-418597Reactome: R-HSA-422356Reactome: R-HSA-9009391Reactome: R-HSA-9634597Reactome: R-HSA-9660821 |
| Cellular Localisation | CytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeCell MembraneMembraneLipid-AnchorLocalizes In The Centrosomes Of Interphase And Mitotic CellsDetected At The Cleavage Furrow And/Or The Midbody |
| Alternative Antibody Names | Anti-Guanine Nucleotide-Binding Protein G(I Subunit Alpha-2 antibodyAnti-Adenylate Cyclase-Inhibiting G Alpha Protein antibodyAnti-GNAI2 antibodyAnti-GNAI2B antibody |
Information sourced from Uniprot.org
