| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | GNAI2 |
| Gene ID: | 2771 |
| Uniprot ID: | GNAI2_HUMAN |
| Immunogen Region: | 1-355 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-355 of human GNAI2 (NP_002061.1). |
| Immunogen Sequence: | MGCTVSAEDKAAAERSKMID KNLREDGEKAAREVKLLLLG AGESGKSTIVKQMKIIHEDG YSEEECRQYRAVVYSNTIQS IMAIVKAMGNLQIDFADPSR ADDARQLFALSCTAEEQGVL PDDLSGVIRRLWADHGVQAC FGRSREYQLNDSAAYYLNDL ERIAQSDYIPTQQDVLRTRV KTTGIVETHFTFKDLHFKMF DVGGQRSERKKWIHCFEGVT AIIFCVALSAYDLVLAEDE |
| Post Translational Modifications | (Microbial infection) Deamidated at Gln-205 by Photorhabdus asymbiotica toxin PAU_02230, blocking GTP hydrolysis of heterotrimeric GNAQ or GNA11 and G-alphai (GNAI1, GNAI2 or GNAI3) proteins, thereby activating RhoA. |
| Function | Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. May play a role in cell division. Isoform sGi2: Regulates the cell surface density of dopamine receptors DRD2 by sequestrating them as an intracellular pool. |
| Protein Name | Guanine Nucleotide-Binding Protein G(I Subunit Alpha-2Adenylate Cyclase-Inhibiting G Alpha Protein |
| Database Links | Reactome: R-HSA-170670Reactome: R-HSA-392170Reactome: R-HSA-400042Reactome: R-HSA-418555Reactome: R-HSA-418594Reactome: R-HSA-418597Reactome: R-HSA-422356Reactome: R-HSA-9009391Reactome: R-HSA-9634597Reactome: R-HSA-9660821 |
| Cellular Localisation | CytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeCell MembraneMembraneLipid-AnchorLocalizes In The Centrosomes Of Interphase And Mitotic CellsDetected At The Cleavage Furrow And/Or The Midbody |
| Alternative Antibody Names | Anti-Guanine Nucleotide-Binding Protein G(I Subunit Alpha-2 antibodyAnti-Adenylate Cyclase-Inhibiting G Alpha Protein antibodyAnti-GNAI2 antibodyAnti-GNAI2B antibody |
Information sourced from Uniprot.org
