| Host: |
Rabbit |
| Applications: |
WB/IHC-P/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
GNA11 |
| Gene ID: |
2767 |
| Uniprot ID: |
GNA11_HUMAN |
| Immunogen Region: |
250-359 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 250-350 of human GNA11 (NP_002058.2). |
| Immunogen Sequence: |
ESKALFRTIITYPWFQNSSV ILFLNKKDLLEDKILYSHLV DYFPEFDGPQRDAQAAREFI LKMFVDLNPDSDKIIYSHFT CATDTENIRFVFAAVKDTIL Q |
| Tissue Specificity | Expressed in testis. |
| Post Translational Modifications | (Microbial infection) Deamidated at Gln-209 by Photorhabdus asymbiotica toxin PAU_02230, blocking GTP hydrolysis of heterotrimeric GNAQ or GNA11 and G-alphai (GNAI1, GNAI2 or GNAI3) proteins, thereby activating RhoA. |
| Function | Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins. Signaling is mediated via phospholipase C-beta-dependent inositol lipid hydrolysis for signal propagation: activates phospholipase C-beta: following GPCR activation, GNA11 activates PLC-beta (PLCB1, PLCB2, PLCB3 or PLCB4), leading to production of diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Transduces FFAR4 signaling in response to long-chain fatty acids (LCFAs). Together with GNAQ, required for heart development. |
| Protein Name | Guanine Nucleotide-Binding Protein Subunit Alpha-11G Alpha-11G-Protein Subunit Alpha-11Guanine Nucleotide-Binding Protein G(Y Subunit Alpha |
| Database Links | Reactome: R-HSA-112043Reactome: R-HSA-202040Reactome: R-HSA-399997Reactome: R-HSA-416476Reactome: R-HSA-418592Reactome: R-HSA-428930Reactome: R-HSA-434316Reactome: R-HSA-456926Reactome: R-HSA-6814122 |
| Cellular Localisation | Cell MembraneLipid-AnchorCytoplasmIn Testicular CellsExpressed Exclusively In The Cytoplasm |
| Alternative Antibody Names | Anti-Guanine Nucleotide-Binding Protein Subunit Alpha-11 antibodyAnti-G Alpha-11 antibodyAnti-G-Protein Subunit Alpha-11 antibodyAnti-Guanine Nucleotide-Binding Protein G(Y Subunit Alpha antibodyAnti-GNA11 antibodyAnti-GA11 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
