Host: | Rabbit |
Applications: | WB |
Reactivity: | Human/Mouse |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description : | Rabbit polyclonal antibody anti-Geminin is suitable for use in Western Blot research applications. |
Clonality : | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Concentration: | 1 mg/mL |
Dilution Range: | WB 1:500-2000 |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | GMNN |
Gene ID: | 51053 |
Uniprot ID: | GEMI_HUMAN |
Specificity: | This antibody detects endogenous levels of Geminin at Human, Mouse |
Immunogen: | Synthesized peptide derived from human Geminin |
Function | Inhibits DNA replication by preventing the incorporation of MCM complex into pre-replication complex (pre-RC). It is degraded during the mitotic phase of the cell cycle. Its destruction at the metaphase-anaphase transition permits replication in the succeeding cell cycle. Inhibits histone acetyltransferase activity of KAT7/HBO1 in a CDT1-dependent manner, inhibiting histone H4 acetylation and DNA replication licensing. Inhibits the transcriptional activity of a subset of Hox proteins, enrolling them in cell proliferative control. |
Protein Name | Geminin |
Database Links | Reactome: R-HSA-68867Reactome: R-HSA-68962Reactome: R-HSA-69052 |
Cellular Localisation | CytoplasmNucleusMainly Cytoplasmic But Can Be Relocalized To The Nucleus |
Alternative Antibody Names | Anti-Geminin antibodyAnti-GMNN antibody |
Information sourced from Uniprot.org