| Host: | Goat |
| Applications: | Pep-ELISA/WB/IHC |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Goat polyclonal antibody anti-Glutathione Peroxidase 1-Isoform 1 (Internal) is suitable for use in ELISA, Western Blot and Immunohistochemistry research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 0.5 mg/mL |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:32000.WB: Approx 22kDa band observed in Human Liver lysates (calculated MW of 22.1kDa according to NP_000572.2). Recommended concentration: 1-3µg/ml.IHC: In paraffin embedded Human Cerebral |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | GPX1 |
| Gene ID: | 2876 |
| Uniprot ID: | GPX1_HUMAN |
| Immunogen Region: | Internal |
| Accession Number: | NP_000572.2 |
| Specificity: | This antibody is expected to recognise isoform 1 ( NP_000572.2) only. |
| Immunogen Sequence: | REALPAPSDDATA |
| Post Translational Modifications | During periods of oxidative stress, Sec-49 may react with a superoxide radical, irreversibly lose hydroselenide and be converted to dehydroalanine. |
| Function | Catalyzes the reduction of hydroperoxides in a glutathione-dependent manner thus regulating cellular redox homeostasis. Can reduce small soluble hydroperoxides such as H2O2, cumene hydroperoxide and tert-butyl hydroperoxide, as well as several fatty acid-derived hydroperoxides. In platelets catalyzes the reduction of 12-hydroperoxyeicosatetraenoic acid, the primary product of the arachidonate 12-lipoxygenase pathway. |
| Protein Name | Glutathione Peroxidase 1Gpx-1Gshpx-1Cellular Glutathione PeroxidasePhospholipid-Hydroperoxide Glutathione Peroxidase Gpx1 |
| Database Links | Reactome: R-HSA-2142688Reactome: R-HSA-2142712Reactome: R-HSA-2142770Reactome: R-HSA-3299685 |
| Cellular Localisation | CytoplasmMitochondrion |
| Alternative Antibody Names | Anti-Glutathione Peroxidase 1 antibodyAnti-Gpx-1 antibodyAnti-Gshpx-1 antibodyAnti-Cellular Glutathione Peroxidase antibodyAnti-Phospholipid-Hydroperoxide Glutathione Peroxidase Gpx1 antibodyAnti-GPX1 antibody |
Information sourced from Uniprot.org