Anti-Glutathione Peroxidase 1 antibody [R05-4V8] (STJA0036240)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthesized peptide derived from human GPX1
General Information
| Short Description | Rabbit monoclonal anti-Glutathione Peroxidase 1 for use in WB and IP in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IP |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R05-4V8 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity Chromatography |
| Dilution Range | WB 1:500-1:1000IP 1:50 |
| Formulation | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | GPX1 |
| Gene ID | 2876 |
| Uniprot ID | GPX1_HUMAN |
| Immunogen | A synthesized peptide derived from human GPX1 |
Additional Info
| Tissue Specificity | Expressed in platelets (at protein level). |
| Post Translational Modifications | During periods of oxidative stress, Sec-49 may react with a superoxide radical, irreversibly lose hydroselenide and be converted to dehydroalanine. |
| Function | Catalyzes the reduction of hydroperoxides in a glutathione-dependent manner thus regulating cellular redox homeostasis. Can reduce small soluble hydroperoxides such as H2O2, cumene hydroperoxide and tert-butyl hydroperoxide, as well as several fatty acid-derived hydroperoxides. In platelets catalyzes the reduction of 12-hydroperoxyeicosatetraenoic acid, the primary product of the arachidonate 12-lipoxygenase pathway. |
| Protein Name | Glutathione Peroxidase 1Gpx-1Gshpx-1Cellular Glutathione PeroxidasePhospholipid-Hydroperoxide Glutathione Peroxidase Gpx1 |
| Database Links | Reactome: R-HSA-2142688Reactome: R-HSA-2142712Reactome: R-HSA-2142770Reactome: R-HSA-3299685 |
| Cellular Localisation | CytoplasmMitochondrion |
| Alternative Antibody Names | Anti-Glutathione Peroxidase 1 antibodyAnti-Gpx-1 antibodyAnti-Gshpx-1 antibodyAnti-Cellular Glutathione Peroxidase antibodyAnti-Phospholipid-Hydroperoxide Glutathione Peroxidase Gpx1 antibodyAnti-GPX1 antibody |
Information sourced from Uniprot.org