Anti-GLP1R antibody (22-116) (STJ115925)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal GLP1R (22-116) antibody for use in WB and ELISA in human and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | GLP1R |
| Gene ID | 2740 |
| Uniprot ID | GLP1R_HUMAN |
| Immunogen Region | 22-116 |
| Immunogen Sequence | GPRPQGATVSLWETVQKWRE YRRQCQRSLTEDPPPATDLF CNRTFDEYACWPDGEPGSFV NVSCPWYLPWASSVPQGHVY RFCTAEGLWLQKDNS |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 22-116 of human GLP1R (NP_002053.3). |
Additional Info
| Post Translational Modifications | N-glycosylation enhances cell surface expression and lengthens receptor half-life by preventing degradation in the ER. |
| Function | G-protein coupled receptor for glucagon-like peptide 1 (GLP-1). Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels. Plays a role in regulating insulin secretion in response to GLP-1. |
| Protein Name | Glucagon-Like Peptide 1 ReceptorGlp-1 ReceptorGlp-1-RGlp-1r |
| Database Links | Reactome: R-HSA-381676Reactome: R-HSA-418555Reactome: R-HSA-420092 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Glucagon-Like Peptide 1 Receptor antibodyAnti-Glp-1 Receptor antibodyAnti-Glp-1-R antibodyAnti-Glp-1r antibodyAnti-GLP1R antibody |
Information sourced from Uniprot.org