Host: | Rabbit |
Applications: | WB/IF/ICC/ELISA |
Reactivity: | Mouse/Rat |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Clonality : | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
Purification: | Affinity purification |
Concentration: | Lot specific |
Dilution Range: | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | GLP1R |
Gene ID: | 2740 |
Uniprot ID: | GLP1R_HUMAN |
Immunogen Region: | 1-140 |
Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-140 of human GLP1R (NP_002053.3). |
Immunogen Sequence: | MAGAPGPLRLALLLLGMVGR AGPRPQGATVSLWETVQKWR EYRRQCQRSLTEDPPPATDL FCNRTFDEYACWPDGEPGSF VNVSCPWYLPWASSVPQGHV YRFCTAEGLWLQKDNSSLPW RDLSECEESKRGERSSPEEQ |
Post Translational Modifications | N-glycosylation enhances cell surface expression and lengthens receptor half-life by preventing degradation in the ER. |
Function | G-protein coupled receptor for glucagon-like peptide 1 (GLP-1). Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels. Plays a role in regulating insulin secretion in response to GLP-1. |
Protein Name | Glucagon-Like Peptide 1 ReceptorGlp-1 ReceptorGlp-1-RGlp-1r |
Database Links | Reactome: R-HSA-381676Reactome: R-HSA-418555Reactome: R-HSA-420092 |
Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
Alternative Antibody Names | Anti-Glucagon-Like Peptide 1 Receptor antibodyAnti-Glp-1 Receptor antibodyAnti-Glp-1-R antibodyAnti-Glp-1r antibodyAnti-GLP1R antibody |
Information sourced from Uniprot.org