| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | S2MR |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | GLO1 |
| Gene ID: | 2739 |
| Uniprot ID: | LGUL_HUMAN |
| Immunogen Region: | 1-100 |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human GLO1 (Q04760). |
| Immunogen Sequence: | MAEPQPPSGGLTDEAALSCC SDADPSTKDFLLQQTMLRVK DPKKSLDFYTRVLGMTLIQK CDFPIMKFSLYFLAYEDKND IPKEKDEKIAWALSRKATLE |
| Post Translational Modifications | Glutathionylation at Cys-139 inhibits enzyme activity. Phosphorylated at Thr-107 in the presence of CaMK2. However, this is a consensus site for phosphorylation by CK2 so phosphorylation may be mediated by CK2 rather than CaMK2. Phosphorylation is induced by TNF and suppresses the TNF-induced transcriptional activity of NF-kappa-B. Exists in a nitric oxide (NO)-modified form. The exact nature of the modification is unknown, but it suppresses the TNF-induced transcriptional activity of NF-kappa-B. |
| Function | Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. Involved in the regulation of TNF-induced transcriptional activity of NF-kappa-B. Required for normal osteoclastogenesis. |
| Protein Name | Lactoylglutathione Lyase Aldoketomutase Glyoxalase I Glx I Ketone-Aldehyde Mutase Methylglyoxalase S-D-Lactoylglutathione Methylglyoxal Lyase |
| Database Links | Reactome: R-HSA-70268 |
| Alternative Antibody Names | Anti-Lactoylglutathione Lyase antibody Anti-Aldoketomutase antibody Anti-Glyoxalase I antibody Anti-Glx I antibody Anti-Ketone-Aldehyde Mutase antibody Anti-Methylglyoxalase antibody Anti-S-D-Lactoylglutathione Methylglyoxal Lyase antibody Anti-GLO1 antibody |
Information sourced from Uniprot.org