| Short Description : | Rabbit polyclonal GLMN (405-594) antibody for use in WB and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | GLMN |
| Gene ID: | 11146 |
| Uniprot ID: | GLMN_HUMAN |
| Immunogen Region: | 405-594 |
| Immunogen Sequence: | RCLLNTSNHSGVEAFIIQNI KNQIDMSLKRTRNNKWFTGP QLISLLDLVLFLPEGAETDL LQNSDRIMASLNLLRYLVIK DNENDNQTGLWTELGNIENN FLKPLHIGLNMSKAHYEAEI KNSQEAQKSKDLCSITVSGE EIPNMPPEMQLKVLHSALFT FDLIESVLARVEELIEIKTK STSEENIGIK |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 405-594 of human GLMN (NP_444504.1). |
| Tissue Specificity | Ubiquitous. |
| Post Translational Modifications | Phosphorylated on tyrosine residues. |
| Function | Isoform 1: Regulatory component of cullin-RING-based SCF (SKP1-Cullin-F-box protein) E3 ubiquitin-protein ligase complexes. Inhibits E3 ubiquitin ligase activity by binding to RBX1 (via RING domain) and inhibiting its interaction with the E2 ubiquitin-conjugating enzyme CDC34. Inhibits RBX1-mediated neddylation of CUL1. Required for normal stability and normal cellular levels of key components of SCF ubiquitin ligase complexes, including FBXW7, RBX1, CUL1, CUL2, CUL3, CUL4A, and thereby contributes to the regulation of CCNE1 and MYC levels. Essential for normal development of the vasculature. Contributes to the regulation of RPS6KB1 phosphorylation. |
| Protein Name | GlomulinFk506-Binding Protein-Associated ProteinFapFkbp-Associated Protein |
| Database Links | Reactome: R-HSA-983168 |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-Glomulin antibodyAnti-Fk506-Binding Protein-Associated Protein antibodyAnti-Fap antibodyAnti-Fkbp-Associated Protein antibodyAnti-GLMN antibodyAnti-FAP48 antibodyAnti-FAP68 antibodyAnti-VMGLOM antibody |
Information sourced from Uniprot.org
