Anti-GLIS2 antibody (442-492 aa) (STJ194229)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human GLIS2 at the amino acid range 442-492
General Information
| Short Description | Rabbit polyclonal anti-Zinc finger protein GLIS2 (442-492 aa) for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | GLIS2 |
| Gene ID | 84662 |
| Uniprot ID | GLIS2_HUMAN |
| Immunogen | Synthesized peptide derived from the human GLIS2 at the amino acid range 442-492 |
| Immunogen Region | 442-492 aa |
| Specificity | This antibody detects endogenous levels of GLIS2 at Human/Mouse |
Additional Info
| Post Translational Modifications | C-terminus cleavage is induced by interaction with CTNND1 and enhanced by Src tyrosine kinase. |
| Function | Can act either as a transcriptional repressor or as a transcriptional activator, depending on the cell context. Acts as a repressor of the Hedgehog signaling pathway. Represses the Hedgehog-dependent expression of Wnt4. Necessary to maintain the differentiated epithelial phenotype in renal cells through the inhibition of SNAI1, which itself induces the epithelial-to-mesenchymal transition. Represses transcriptional activation mediated by CTNNB1 in the Wnt signaling pathway. May act by recruiting the corepressors CTBP1 and HDAC3. May be involved in neuron differentiation. |
| Protein Name | Zinc Finger Protein Glis2Gli-Similar 2Neuronal Krueppel-Like Protein |
| Database Links | |
| Cellular Localisation | Nucleus SpeckleCytoplasm |
| Alternative Antibody Names | Anti-Zinc Finger Protein Glis2 antibodyAnti-Gli-Similar 2 antibodyAnti-Neuronal Krueppel-Like Protein antibodyAnti-GLIS2 antibodyAnti-NKL antibody |
Information sourced from Uniprot.org