| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Zinc finger protein GLI2 is suitable for use in Western Blot and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000ELISA 1:5000-20000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
GLI2 |
| Gene ID: |
2736 |
| Uniprot ID: |
GLI2_HUMAN |
| Specificity: |
GLI2 Polyclonal Antibody detects endogenous levels of protein. |
| Immunogen: |
Synthesized peptide derived from part of the human protein |
| Post Translational Modifications | Phosphorylated in vitro by ULK3. Phosphorylated by DYRK2.this inhibits GLI2 transcription factor activity and promotes proteasomal degradation of GLI2. Acetylation at Lys-757 inhibits Hh target gene expression, probably by impeding entry into chromatin thus preventing promoter occupancy. |
| Function | Functions as a transcription regulator in the hedgehog (Hh) pathway. Functions as a transcriptional activator. May also function as transcriptional repressor. Requires STK36 for full transcriptional activator activity. Required for normal embryonic development. Isoform 1: Involved in the smoothened (SHH) signaling pathway. Isoform 2: Involved in the smoothened (SHH) signaling pathway. Isoform 3: Involved in the smoothened (SHH) signaling pathway. Isoform 4: Involved in the smoothened (SHH) signaling pathway. Isoform 1: Acts as a transcriptional activator in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1. Isoform 2: (Microbial infection) Acts as a transcriptional activators in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1. Isoform 3: (Microbial infection) Acts as a transcriptional activators in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1. Isoform 4: (Microbial infection) Acts as a transcriptional activators in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1. Isoform 5: Acts as a transcriptional repressor. |
| Protein Name | Zinc Finger Protein Gli2Gli Family Zinc Finger Protein 2Tax Helper Protein |
| Database Links | Reactome: R-HSA-5610783Reactome: R-HSA-5610787Reactome: R-HSA-5632684Reactome: R-HSA-5635851Reactome: R-HSA-8941284 |
| Cellular Localisation | NucleusCytoplasmCell ProjectionCiliumStk36 Promotes Translocation To The NucleusIn KeratinocytesIt Is Sequestered In The Cytoplasm By SufuIn The Absence Of SufuIt Translocates To The NucleusIsoform 1: NucleusIsoform 2: Nucleus |
| Alternative Antibody Names | Anti-Zinc Finger Protein Gli2 antibodyAnti-Gli Family Zinc Finger Protein 2 antibodyAnti-Tax Helper Protein antibodyAnti-GLI2 antibodyAnti-THP antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
