| Tissue Specificity | Expressed in breast cancers (at protein level). Isoform 1 and isoform 4 are expressed in HTLV-1-infected T-cell lines (at protein level). Isoform 1 and isoform 2 are strongly expressed in HTLV-1-infected T-cell lines. Isoform 3 and isoform 4 are weakly expressed in HTLV-1-infected T-cell lines. |
| Post Translational Modifications | Phosphorylated in vitro by ULK3. Phosphorylated by DYRK2.this inhibits GLI2 transcription factor activity and promotes proteasomal degradation of GLI2. Acetylation at Lys-757 inhibits Hh target gene expression, probably by impeding entry into chromatin thus preventing promoter occupancy. |
| Function | Functions as a transcription regulator in the hedgehog (Hh) pathway. Functions as a transcriptional activator. May also function as transcriptional repressor. Requires STK36 for full transcriptional activator activity. Required for normal embryonic development. Isoform 1: Involved in the smoothened (SHH) signaling pathway. Isoform 2: Involved in the smoothened (SHH) signaling pathway. Isoform 3: Involved in the smoothened (SHH) signaling pathway. Isoform 4: Involved in the smoothened (SHH) signaling pathway. Isoform 1: Acts as a transcriptional activator in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1. Isoform 2: (Microbial infection) Acts as a transcriptional activators in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1. Isoform 3: (Microbial infection) Acts as a transcriptional activators in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1. Isoform 4: (Microbial infection) Acts as a transcriptional activators in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1. Isoform 5: Acts as a transcriptional repressor. |
| Protein Name | Zinc Finger Protein Gli2Gli Family Zinc Finger Protein 2Tax Helper Protein |
| Database Links | Reactome: R-HSA-5610783Reactome: R-HSA-5610787Reactome: R-HSA-5632684Reactome: R-HSA-5635851Reactome: R-HSA-8941284 |
| Cellular Localisation | NucleusCytoplasmCell ProjectionCiliumStk36 Promotes Translocation To The NucleusIn KeratinocytesIt Is Sequestered In The Cytoplasm By SufuIn The Absence Of SufuIt Translocates To The NucleusIsoform 1: NucleusIsoform 2: Nucleus |
| Alternative Antibody Names | Anti-Zinc Finger Protein Gli2 antibodyAnti-Gli Family Zinc Finger Protein 2 antibodyAnti-Tax Helper Protein antibodyAnti-GLI2 antibodyAnti-THP antibody |
Information sourced from Uniprot.org
