| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CRG-L2 (Internal Region) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS + 0.02% NaN3 |
| Purification: |
Antigen Affinity Purified |
| Dilution Range: |
WB 1:500-1:1000IHCICCIP |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
GLDN |
| Gene ID: |
342035 |
| Uniprot ID: |
GLDN_HUMAN |
| Immunogen Region: |
Internal Region |
| Specificity: |
Reacts with an internal region of the human CRG-L2 protein. |
| Immunogen: |
Synthetic peptide corresponding to amino acids from an internal region of the human CRG-L2 protein. |
| Post Translational Modifications | N-glycosylated. Proteolytic proccessing by a furin-like protease causes shedding of the ectodomain. Further cleavage by BMP1 releases the olfactomedin-like domain. |
| Function | Ligand for NRCAM and NFASC/neurofascin that plays a role in the formation and maintenance of the nodes of Ranvier on myelinated axons. Mediates interaction between Schwann cell microvilli and axons via its interactions with NRCAM and NFASC. Nodes of Ranvier contain clustered sodium channels that are crucial for the saltatory propagation of action potentials along myelinated axons. During development, nodes of Ranvier are formed by the fusion of two heminodes. Required for normal clustering of sodium channels at heminodes.not required for the formation of mature nodes with normal sodium channel clusters. Required, together with NRCAM, for maintaining NFASC and sodium channel clusters at mature nodes of Ranvier. |
| Protein Name | Gliomedin Cleaved Into - Gliomedin Shedded Ectodomain |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane ProteinCell ProjectionAxonDetected At The Nodes Of RanvierDetected At Immature HeminodesGliomedin Shedded Ectodomain: SecretedSecretedExtracellular SpaceExtracellular MatrixProteolytic Processing Gives Rise To A Soluble Extracellular Domain That Is SecretedThe Gliomedin Shedded Ectodomain Localizes To The Nodes Of Ranvier |
| Alternative Antibody Names | Anti-Gliomedin Cleaved Into - Gliomedin Shedded Ectodomain antibodyAnti-GLDN antibodyAnti-COLM antibodyAnti-UNQ9339 antibodyAnti-PRO34011 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
