Anti-GLB1 antibody [R01-3G1] (STJA0034365)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide of human GLB1
General Information
| Short Description | Rabbit monoclonal anti-GLB1 for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R01-3G1 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.3 mg/mL |
| Purification | Affinity Purified |
| Dilution Range | WB 1:500-1:1000 |
| Formulation | 50mM Tris-Glycine (pH 7.4) , 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | GLB1 |
| Gene ID | 2720 |
| Uniprot ID | BGAL_HUMAN |
| Immunogen | A synthetic peptide of human GLB1 |
Additional Info
| Tissue Specificity | Detected in placenta (at protein level). Detected in fibroblasts and testis. |
| Function | Isoform 1: Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans. Isoform 2: Has no beta-galactosidase catalytic activity, but plays functional roles in the formation of extracellular elastic fibers (elastogenesis) and in the development of connective tissue. Seems to be identical to the elastin-binding protein (EBP), a major component of the non-integrin cell surface receptor expressed on fibroblasts, smooth muscle cells, chondroblasts, leukocytes, and certain cancer cell types. In elastin producing cells, associates with tropoelastin intracellularly and functions as a recycling molecular chaperone which facilitates the secretions of tropoelastin and its assembly into elastic fibers. |
| Protein Name | Beta-GalactosidaseAcid Beta-GalactosidaseLactaseElastin Receptor 1 |
| Database Links | Reactome: R-HSA-2022857Reactome: R-HSA-2024096Reactome: R-HSA-2206308Reactome: R-HSA-4085001Reactome: R-HSA-4341670Reactome: R-HSA-6798695Reactome: R-HSA-9840310 |
| Cellular Localisation | Isoform 1: LysosomeIsoform 2: CytoplasmPerinuclear RegionLocalized To The Perinuclear Area Of The Cytoplasm But Not To Lysosomes |
| Alternative Antibody Names | Anti-Beta-Galactosidase antibodyAnti-Acid Beta-Galactosidase antibodyAnti-Lactase antibodyAnti-Elastin Receptor 1 antibodyAnti-GLB1 antibodyAnti-ELNR1 antibody |
Information sourced from Uniprot.org