| Tissue Specificity | Expressed at high levels in the small intestine, ovary, testis, kidney and endothelial cells. |
| Function | Cytokine that binds to TNFRSF18/AITR/GITR. Regulates T-cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B. Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1. Promotes leukocyte adhesion to endothelial cells. Regulates migration of monocytes from the splenic reservoir to sites of inflammation. |
| Protein Name | Tumor Necrosis Factor Ligand Superfamily Member 18Activation-Inducible Tnf-Related LigandAitrlGlucocorticoid-Induced Tnf-Related LigandHgitrl |
| Database Links | Reactome: R-HSA-5669034 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane Protein |
| Alternative Antibody Names | Anti-Tumor Necrosis Factor Ligand Superfamily Member 18 antibodyAnti-Activation-Inducible Tnf-Related Ligand antibodyAnti-Aitrl antibodyAnti-Glucocorticoid-Induced Tnf-Related Ligand antibodyAnti-Hgitrl antibodyAnti-TNFSF18 antibodyAnti-AITRL antibodyAnti-GITRL antibodyAnti-TL6 antibodyAnti-UNQ149 antibodyAnti-PRO175 antibody |
Information sourced from Uniprot.org
