| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | GGH |
| Gene ID: | 8836 |
| Uniprot ID: | GGH_HUMAN |
| Immunogen Region: | 25-230 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 25-230 of human GGH (NP_003869.1). |
| Immunogen Sequence: | RPHGDTAKKPIIGILMQKCR NKVMKNYGRYYIAASYVKYL ESAGARVVPVRLDLTEKDYE ILFKSINGILFPGGSVDLRR SDYAKVAKIFYNLSIQSFDD GDYFPVWGTCLGFEELSLLI SGECLLTATDTVDVAMPLNF TGGQLHSRMFQNFPTELLLS LAVEPLTANFHKWSLSVKNF TMNEKLKKFFNVLTTNTDGK IEFIST |
| Function | Hydrolyzes the polyglutamate sidechains of pteroylpolyglutamates. Progressively removes gamma-glutamyl residues from pteroylpoly-gamma-glutamate to yield pteroyl-alpha-glutamate (folic acid) and free glutamate. May play an important role in the bioavailability of dietary pteroylpolyglutamates and in the metabolism of pteroylpolyglutamates and antifolates. |
| Protein Name | Gamma-Glutamyl HydrolaseConjugaseGhGamma-Glu-X Carboxypeptidase |
| Database Links | Reactome: R-HSA-6798695 |
| Cellular Localisation | SecretedExtracellular SpaceLysosomeMelanosomeWhile Its Intracellular Location Is Primarily The LysosomeMost Of The Enzyme Activity Is SecretedIdentified By Mass Spectrometry In Melanosome Fractions From Stage I To Stage Iv |
| Alternative Antibody Names | Anti-Gamma-Glutamyl Hydrolase antibodyAnti-Conjugase antibodyAnti-Gh antibodyAnti-Gamma-Glu-X Carboxypeptidase antibodyAnti-GGH antibody |
Information sourced from Uniprot.org