| Short Description : | Rabbit polyclonal GGA2 (1-300) antibody for use in WB, IF, ICC and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/IF/ICC/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | GGA2 |
| Gene ID: | 23062 |
| Uniprot ID: | GGA2_HUMAN |
| Immunogen Region: | 1-300 |
| Immunogen Sequence: | MAATAVAAAVAGTESAQGPP GPAASLELWLNKATDPSMSE QDWSAIQNFCEQVNTDPNGP THAPWLLAHKIQSPQEKEAL YALTVLEMCMNHCGEKFHSE VAKFRFLNELIKVLSPKYLG SWATGKVKGRVIEILFSWTV WFPEDIKIRDAYQMLKKQGI IKQDPKLPVDKILPPPSPWP KSSIFDADEEKSKLLTRLLK SNHPEDLQAANRLIKNLVKE EQEKSEKVSKRVSAVEEVR |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human GGA2 (NP_055859.1). |
| Tissue Specificity | Ubiquitously expressed. |
| Post Translational Modifications | Ubiquitinated. |
| Function | Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif. Mediates export of the GPCR receptor ADRA2B to the cell surface. Regulates retrograde transport of phosphorylated form of BACE1 from endosomes to the trans-Golgi network. |
| Protein Name | Adp-Ribosylation Factor-Binding Protein Gga2Gamma-Adaptin-Related Protein 2Golgi-Localized - Gamma Ear-Containing - Arf-Binding Protein 2Vhs Domain And Ear Domain Of Gamma-AdaptinVear |
| Database Links | Reactome: R-HSA-8854214Reactome: R-HSA-977225 |
| Cellular Localisation | Golgi ApparatusTrans-Golgi Network MembranePeripheral Membrane ProteinEndosome MembraneEarly Endosome Membrane |
| Alternative Antibody Names | Anti-Adp-Ribosylation Factor-Binding Protein Gga2 antibodyAnti-Gamma-Adaptin-Related Protein 2 antibodyAnti-Golgi-Localized - Gamma Ear-Containing - Arf-Binding Protein 2 antibodyAnti-Vhs Domain And Ear Domain Of Gamma-Adaptin antibodyAnti-Vear antibodyAnti-GGA2 antibodyAnti-KIAA1080 antibody |
Information sourced from Uniprot.org
