| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Rat/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-GDNF family receptor alpha-4 (141-190 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-1:2000ELISA 1:10000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
GFRA4 |
| Gene ID: |
64096 |
| Uniprot ID: |
GFRA4_HUMAN |
| Immunogen Region: |
141-190 aa |
| Specificity: |
GFR Alpha-4 Polyclonal Antibody detects endogenous levels of GFR Alpha-4 protein. |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from the human GFRA4 at the amino acid range 141-190 |
| Function | Receptor for persephin (PSPN), a growth factor that exhibits neurotrophic activity on mesencephalic dopaminergic and motor neurons. Acts by binding to its coreceptor, GFRA4, leading to autophosphorylation and activation of the RET receptor. May be important in C-cell development and, in the postnatal development of the adrenal medulla. |
| Protein Name | Gdnf Family Receptor Alpha-4Gdnf Receptor Alpha-4Gdnfr-Alpha-4Gfr-Alpha-4Persephin Receptor |
| Database Links | Reactome: R-HSA-419037Reactome: R-HSA-5673001Reactome: R-HSA-8853659 |
| Cellular Localisation | Isoform Gfralpha4a: Cell MembraneLipid-AnchorGpi-AnchorIsoform Gfralpha4b: Cell MembraneIsoform Gfralpha4c: Secreted |
| Alternative Antibody Names | Anti-Gdnf Family Receptor Alpha-4 antibodyAnti-Gdnf Receptor Alpha-4 antibodyAnti-Gdnfr-Alpha-4 antibodyAnti-Gfr-Alpha-4 antibodyAnti-Persephin Receptor antibodyAnti-GFRA4 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
