| Post Translational Modifications | Palmitoylated. Palmitoylation is stimulated by GABA type A receptors activity. Palmitoylation by ZDHHC12 regulates clustering at synapses. |
| Function | Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules. Acts as a major instructive molecule at inhibitory synapses, where it also clusters GABA type A receptors. Also has a catalytic activity and catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released. |
| Protein Name | Gephyrin Includes - Molybdopterin AdenylyltransferaseMpt AdenylyltransferaseDomain G - Molybdopterin MolybdenumtransferaseMpt Mo-TransferaseDomain E |
| Database Links | Reactome: R-HSA-947581 |
| Cellular Localisation | Postsynaptic Cell MembraneLipid-AnchorCytoplasmic SideCell MembraneCytoplasmCytosolCytoskeletonCell ProjectionDendritePostsynaptic DensityCytoplasmic Face Of Glycinergic Postsynaptic MembranesForms Clusters At Synapses |
| Alternative Antibody Names | Anti-Gephyrin Includes - Molybdopterin Adenylyltransferase antibodyAnti-Mpt Adenylyltransferase antibodyAnti-Domain G - Molybdopterin Molybdenumtransferase antibodyAnti-Mpt Mo-Transferase antibodyAnti-Domain E antibodyAnti-GPHN antibodyAnti-GPH antibodyAnti-KIAA1385 antibody |
Information sourced from Uniprot.org
