| Host: |
Rabbit |
| Applications: |
IHC/WB |
| Reactivity: |
Human/Rat/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Gephyrin (C-Term) is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Lyophilised |
| Purification: |
IgG purified |
| Dilution Range: |
IHC, WB. A dilution of 1:1000 is recommended. The optimal dilution should be determined by the end user. Not tested in other applications. |
| Storage Instruction: |
Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: |
GPHN |
| Gene ID: |
10243 |
| Uniprot ID: |
GEPH_HUMAN |
| Immunogen Region: |
C-Term |
| Specificity: |
Specific for Gephyrin. |
| Immunogen: |
A synthetic peptide from the c-terminal of human Gephyrin (GPHN) conjugated to blue carrier protein was used as the antigen. |
| Function | Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules. Acts as a major instructive molecule at inhibitory synapses, where it also clusters GABA type A receptors. Has also a catalytic activity and catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released. |
| Protein Name | Gephyrin Includes - Molybdopterin AdenylyltransferaseMpt AdenylyltransferaseDomain G - Molybdopterin MolybdenumtransferaseMpt Mo-TransferaseDomain E |
| Database Links | Reactome: R-HSA-947581 |
| Cellular Localisation | Postsynaptic Cell MembraneLipid-AnchorCytoplasmic SideCell MembraneCytoplasmCytosolCytoskeletonCell ProjectionDendritePostsynaptic DensityCytoplasmic Face Of Glycinergic Postsynaptic MembranesForms Clusters At Synapses |
| Alternative Antibody Names | Anti-Gephyrin Includes - Molybdopterin Adenylyltransferase antibodyAnti-Mpt Adenylyltransferase antibodyAnti-Domain G - Molybdopterin Molybdenumtransferase antibodyAnti-Mpt Mo-Transferase antibodyAnti-Domain E antibodyAnti-GPHN antibodyAnti-GPH antibodyAnti-KIAA1385 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
