Anti-GEMIN8 antibody [ZN185] (STJA0033357)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1
ImmunogenFull length human recombinant protein of human GEMIN8 (NP_060326) produced in E.coli.
General Information
| Short Description | Mouse monoclonal anti-GEMIN8 for use in IHC-P in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC-P |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | ZN185 |
| Isotype | IgG1 |
| Conjugation | Unconjugated |
| Concentration | 0.5-1.0 mg/mL |
| Purification | Affinity Chromatography |
| Dilution Range | IHC 1:50-1:100 |
| Formulation | PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | GEMIN8 |
| Gene ID | 54960 |
| Uniprot ID | GEMI8_HUMAN |
| Immunogen | Full length human recombinant protein of human GEMIN8 (NP_060326) produced in E.coli. |
Additional Info
| Function | The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. |
| Protein Name | Gem-Associated Protein 8Gemin-8Protein Fam51a1 |
| Database Links | Reactome: R-HSA-191859Reactome: R-HSA-9754678 |
| Cellular Localisation | NucleusGemCytoplasmFound In Nuclear Bodies Called Gems (Gemini Of Cajal Bodies) That Are Often In Proximity To Cajal (Coiled) BodiesAlso Found In The Cytoplasm |
| Alternative Antibody Names | Anti-Gem-Associated Protein 8 antibodyAnti-Gemin-8 antibodyAnti-Protein Fam51a1 antibodyAnti-GEMIN8 antibodyAnti-FAM51A1 antibody |
Information sourced from Uniprot.org