| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-GEMIN8 (1-242) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
GEMIN8 |
| Gene ID: |
54960 |
| Uniprot ID: |
GEMI8_HUMAN |
| Immunogen Region: |
1-242 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-242 of human GEMIN8 (NP_060326.1). |
| Immunogen Sequence: |
MAAVKASTSKATRPWYSHPV YARYWQHYHQAMAWMQSHHN AYRKAVESCFNLPWYLPSAL LPQSSYDNEAAYPQSFYDHH VAWQDYPCSSSHFRRSGQHP RYSSRIQASTKEDQALSKEE EMETESDAEVECDLSNMEIT EELRQYFAETERHREERRRQ QQLDAERLDSYVNADHDLYC NTRRSVEAPTERPGERRQAE MKRLYGDSAAKIQAMEAAVQ LSFDKHCDRKQPKYWPVIP |
| Function | The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. |
| Protein Name | Gem-Associated Protein 8Gemin-8Protein Fam51a1 |
| Database Links | Reactome: R-HSA-191859Reactome: R-HSA-9754678 |
| Cellular Localisation | NucleusGemCytoplasmFound In Nuclear Bodies Called Gems (Gemini Of Cajal Bodies) That Are Often In Proximity To Cajal (Coiled) BodiesAlso Found In The Cytoplasm |
| Alternative Antibody Names | Anti-Gem-Associated Protein 8 antibodyAnti-Gemin-8 antibodyAnti-Protein Fam51a1 antibodyAnti-GEMIN8 antibodyAnti-FAM51A1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
