Anti-GDNF family receptor alpha-3 antibody (STJA0040697)
SPECIFICATIONS
ClonalityPolyclonal
HostChicken
ConjugationUnconjugated
IsotypeIgY
ImmunogenRecombinant His-tagged human GFRa-3 protein produced using CHO-based cell line. For production of hGFRa-3, glycosylphosphatidyl-inositol GPI-anchor was removed and protein was secreted to the cell culture supernatant. Protein was purified by Ni-affin
General Information
| Short Description | Chicken polyclonal anti-GDNF family receptor alpha-3 for use in ICC and WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | ICC/WB |
| Host | Chicken |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgY |
| Conjugation | Unconjugated |
| Purification | Affinity-purified |
| Dilution Range | WB 1:5000-1:10000ICC 1:1500-1:3000 |
| Formulation | Concentrated ammonium sulphate in PBS pH 7.4 containing no preservatives. |
| Storage Instruction | Store antibody stock solution at +4°C upon receipt. DO NOT FREEZE. This product is an (NH4) 2SO4 precipitate. To use, mix well by pipetting or vortexing gently prior use, then withdraw the desired amount of antibody stock solution and dilute into you |
Target Information
| Gene Symbol | GFRA3 |
| Gene ID | 2676 |
| Uniprot ID | GFRA3_HUMAN |
| Immunogen | Recombinant His-tagged human GFRa-3 protein produced using CHO-based cell line. For production of hGFRa-3, glycosylphosphatidyl-inositol GPI-anchor was removed and protein was secreted to the cell culture supernatant. Protein was purified by Ni-affin |
| Immunogen Sequence | Human |
| Specificity | Human GFRa-3. No cross-reactivity with hGFRa-1, hGFRa-2, hGFRa-4. |
Additional Info
| Tissue Specificity | Widely expressed in adult and fetus which exhibit a similar pattern. Essentially not expressed in the central nervous system, but highly expressed in several sensory and sympathetic ganglia of the peripheral nervous system. Moderate expression in many non-neuronal tissues, particularly those of the digestive and urogenital systems, but high expression in stomach and appendix. Several types of glandular tissues show low expression. Very low or no expression detected in the hematopoietic system. |
| Post Translational Modifications | N-glycosylated. |
| Function | Receptor for artemin (ARTN), a growth factor that supports the survival of sensory and sympathetic peripheral neurons. ARTN-binding leads to autophosphorylation and activation of the RET receptor. |
| Protein Name | Gdnf Family Receptor Alpha-3Gdnf Receptor Alpha-3Gdnfr-Alpha-3Gfr-Alpha-3 |
| Database Links | Reactome: R-HSA-5673001Reactome: R-HSA-8853659 |
| Cellular Localisation | Cell MembraneLipid-AnchorGpi-Anchor |
| Alternative Antibody Names | Anti-Gdnf Family Receptor Alpha-3 antibodyAnti-Gdnf Receptor Alpha-3 antibodyAnti-Gdnfr-Alpha-3 antibodyAnti-Gfr-Alpha-3 antibodyAnti-GFRA3 antibodyAnti-UNQ339 antibodyAnti-PRO538 antibodyAnti-PRO3664 antibody |
Information sourced from Uniprot.org