Anti-GDF-15 antibody [4901] (STJ400288)

SKU:
STJ400288

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Host: Mouse
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-GDF-15 is suitable for use in ELISA research applications.
Clonality: Monoclonal
Clone ID: 4901
Conjugation: Unconjugated
Isotype: IgG1
Formulation: 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
Concentration: 5.0 mg/ml (+/-10 %)
Storage Instruction: Unspecified, storage at 2–8 °C
Association Rate Constant: Not Determined (N/D)
Immunoreactivity: 80–120 % compared to the reference sample in an FIA test
Gene Symbol: GDF15
Gene ID: 9518
Uniprot ID: GDF15_HUMAN
Specificity: Antibody recognizes human growth differentiation factor 15 (GDF-15)
Immunogen: N/D
Tissue Specificity Highly expressed in placenta, with lower levels in prostate and colon and some expression in kidney. Detected in plasma (at protein level).
Function Regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses. Binds to its receptor, GFRAL, and activates GFRAL-expressing neurons localized in the area postrema and nucleus tractus solitarius of the brainstem. It then triggers the activation of neurons localized within the parabrachial nucleus and central amygdala, which constitutes part of the 'emergency circuit' that shapes feeding responses to stressful conditions. On hepatocytes, inhibits growth hormone signaling.
Protein Name Growth/Differentiation Factor 15
Gdf-15
Macrophage Inhibitory Cytokine 1
Mic-1
Nsaid-Activated Gene 1 Protein
Nag-1
Nsaid-Regulated Gene 1 Protein
Nrg-1
Placental Tgf-Beta
Placental Bone Morphogenetic Protein
Prostate Differentiation Factor
Cellular Localisation Secreted
Alternative Antibody Names Anti-Growth/Differentiation Factor 15 antibody
Anti-Gdf-15 antibody
Anti-Macrophage Inhibitory Cytokine 1 antibody
Anti-Mic-1 antibody
Anti-Nsaid-Activated Gene 1 Protein antibody
Anti-Nag-1 antibody
Anti-Nsaid-Regulated Gene 1 Protein antibody
Anti-Nrg-1 antibody
Anti-Placental Tgf-Beta antibody
Anti-Placental Bone Morphogenetic Protein antibody
Anti-Prostate Differentiation Factor antibody
Anti-GDF15 antibody
Anti-MIC1 antibody
Anti-PDF antibody
Anti-PLAB antibody
Anti-PTGFB antibody

Information sourced from Uniprot.org

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