| Host: |
Mouse |
| Applications: |
ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Mouse monoclonal antibody anti-GDF-15 is suitable for use in ELISA research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
4901 |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG1 |
| Formulation: |
50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative |
| Concentration: |
5.0 mg/ml (+/-10 %) |
| Storage Instruction: |
Unspecified, storage at 2–8 °C |
| Association Rate Constant: |
Not Determined (N/D) |
| Immunoreactivity: |
80–120 % compared to the reference sample in an FIA test |
| Gene Symbol: |
GDF15 |
| Gene ID: |
9518 |
| Uniprot ID: |
GDF15_HUMAN |
| Specificity: |
Antibody recognizes human growth differentiation factor 15 (GDF-15) |
| Immunogen: |
N/D |
| Tissue Specificity | Highly expressed in placenta, with lower levels in prostate and colon and some expression in kidney. Detected in plasma (at protein level). |
| Function | Regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses. Binds to its receptor, GFRAL, and activates GFRAL-expressing neurons localized in the area postrema and nucleus tractus solitarius of the brainstem. It then triggers the activation of neurons localized within the parabrachial nucleus and central amygdala, which constitutes part of the 'emergency circuit' that shapes feeding responses to stressful conditions. On hepatocytes, inhibits growth hormone signaling. |
| Protein Name | Growth/Differentiation Factor 15Gdf-15Macrophage Inhibitory Cytokine 1Mic-1Nsaid-Activated Gene 1 ProteinNag-1Nsaid-Regulated Gene 1 ProteinNrg-1Placental Tgf-BetaPlacental Bone Morphogenetic ProteinProstate Differentiation Factor |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Growth/Differentiation Factor 15 antibodyAnti-Gdf-15 antibodyAnti-Macrophage Inhibitory Cytokine 1 antibodyAnti-Mic-1 antibodyAnti-Nsaid-Activated Gene 1 Protein antibodyAnti-Nag-1 antibodyAnti-Nsaid-Regulated Gene 1 Protein antibodyAnti-Nrg-1 antibodyAnti-Placental Tgf-Beta antibodyAnti-Placental Bone Morphogenetic Protein antibodyAnti-Prostate Differentiation Factor antibodyAnti-GDF15 antibodyAnti-MIC1 antibodyAnti-PDF antibodyAnti-PLAB antibodyAnti-PTGFB antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
