| Applications: | IF/ICC/ELISA |
| Host: | Rabbit |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | SRM5429 |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | IF/ICC:1:100-1:400ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.09% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | GCSH |
| Gene ID: | 2653 |
| Uniprot ID: | GCSH_HUMAN |
| Immunogen Region: | 49-173 aa |
| Immunogen Sequence: | SVRKFTEKHEWVTTENGIGT VGISNFAQEALGDVVYCSLP EVGTKLNKQDEFGALESVKA ASELYSPLSGEVTEINEALA ENPGLVNKSCYEDGWLIKMT LSNPSELDELMSEEAYEKYI KSIEE |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 49-173 of human GCSH (NP_004474.2). |
| Function | The glycine cleavage system catalyzes the degradation of glycine. The H protein (GCSH) shuttles the methylamine group of glycine from the P protein (GLDC) to the T protein (GCST). Has a pivotal role in the lipoylation of enzymes involved in cellular energetics such as the mitochondrial dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex (DLAT), and the mitochondrial dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex (DLST). |
| Protein Name | Glycine Cleavage System H Protein - MitochondrialLipoic Acid-Containing Protein |
| Database Links | Reactome: R-HSA-6783984Reactome: R-HSA-9857492 |
| Cellular Localisation | Mitochondrion |
| Alternative Antibody Names | Anti-Glycine Cleavage System H Protein - Mitochondrial antibodyAnti-Lipoic Acid-Containing Protein antibodyAnti-GCSH antibody |
Information sourced from Uniprot.org
