| Short Description : | Rabbit polyclonal anti-Glucokinase regulatory protein (211-260 aa) for use in WB and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | 1 mg/mL |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range: | WB 1:500-1:2000ELISA 1:40000 |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | GCKR |
| Gene ID: | 2646 |
| Uniprot ID: | GCKR_HUMAN |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human Glucokinase Regulator at the amino acid range 211-260 |
| Immunogen Region: | 211-260 aa |
| Specificity: | GCKR Polyclonal Antibody detects endogenous levels of GCKR protein. |
| Function | Regulates glucokinase (GCK) by forming an inactive complex with this enzyme. Acts by promoting GCK recruitment to the nucleus, possibly to provide a reserve of GCK that can be quickly released in the cytoplasm after a meal. The affinity of GCKR for GCK is modulated by fructose metabolites: GCKR with bound fructose 6-phosphate has increased affinity for GCK, while GCKR with bound fructose 1-phosphate has strongly decreased affinity for GCK and does not inhibit GCK activity. |
| Protein Name | Glucokinase Regulatory ProteinGkrpGlucokinase Regulator |
| Database Links | Reactome: R-HSA-170822Reactome: R-HSA-5619107 |
| Cellular Localisation | CytoplasmNucleusMitochondrionUnder Low Glucose ConcentrationsGckr Associates With Gck And The Inactive Complex Is Recruited To The Hepatocyte Nucleus |
| Alternative Antibody Names | Anti-Glucokinase Regulatory Protein antibodyAnti-Gkrp antibodyAnti-Glucokinase Regulator antibodyAnti-GCKR antibody |
Information sourced from Uniprot.org
