| Short Description : | Rabbit polyclonal GCDH (149-438) antibody for use in WB, IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/IHC-P/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:200-1:2000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | GCDH |
| Gene ID: | 2639 |
| Uniprot ID: | GCDH_HUMAN |
| Immunogen Region: | 149-438 |
| Immunogen Sequence: | MHPIYAYGSEEQRQKYLPQL AKGELLGCFGLTEPNSGSDP SSMETRAHYNSSNKSYTLNG TKTWITNSPMADLFVVWARC EDGCIRGFLLEKGMRGLSAP RIQGKFSLRASATGMIIMDG VEVPEENVLPGASSLGGPFG CLNNARYGIAWGVLGASEFC LHTARQYALDRMQFGVPLAR NQLIQKKLADMLTEITLGLH ACLQLGRLKDQDKAAPEMVS LLKRNNCGKALDIARQARD |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 149-438 of human GCDH (NP_000150.1). |
| Tissue Specificity | Isoform Long and isoform Short are expressed in fibroblasts and liver. |
| Function | Catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO(2) in the degradative pathway of L-lysine, L-hydroxylysine, and L-tryptophan metabolism. It uses electron transfer flavoprotein as its electron acceptor. Isoform Short is inactive. |
| Protein Name | Glutaryl-Coa Dehydrogenase - MitochondrialGcd |
| Database Links | Reactome: R-HSA-71064 |
| Cellular Localisation | Mitochondrion Matrix |
| Alternative Antibody Names | Anti-Glutaryl-Coa Dehydrogenase - Mitochondrial antibodyAnti-Gcd antibodyAnti-GCDH antibody |
Information sourced from Uniprot.org
