Anti-GBA3 antibody (1-162) (STJ110137)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal GBA3 (1-162) antibody for use in WB, IF, ICC and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IF/ICC:1:50-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | GBA3 |
| Gene ID | 57733 |
| Uniprot ID | GBA3_HUMAN |
| Immunogen Region | 1-162 |
| Immunogen Sequence | MAFPAGFGWAAATAAYQVEG GWDADGKGPCVWDTFTHQGG ERVFKNQTGDVACGSYTLWE EDLKCIKQLGLTHYRFSLSW SRLLPDGTTGFINQKAIQLD KVNLQVYCAWSLLDNFEWNQ GYSSRFGLFHVDFEDPARPR VPYTSAKEYAKIIRNNGLEA HL |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-162 of human GBA3 (NP_001121904.1). |
Additional Info
| Tissue Specificity | Present in small intestine (at protein level). Expressed in liver, small intestine, colon, spleen and kidney. Down-regulated in renal cell carcinomas and hepatocellular carcinomas. |
| Post Translational Modifications | The N-terminus is blocked. |
| Function | Neutral cytosolic beta-glycosidase with a broad substrate specificity that could play a role in the catabolism of glycosylceramides. Has a significant glucosylceramidase activity in vitro. However, that activity is relatively low and its significance in vivo is not clear. Hydrolyzes galactosylceramides/GalCers, glucosylsphingosines/GlcSphs and galactosylsphingosines/GalSphs. However, the in vivo relevance of these activities is unclear. It can also hydrolyze a broad variety of dietary glycosides including phytoestrogens, flavonols, flavones, flavanones and cyanogens in vitro and could therefore play a role in the metabolism of xenobiotics. Possesses transxylosylase activity in vitro using xylosylated ceramides/XylCers (such as beta-D-xylosyl-(1<->1')-N-acylsphing-4-enine) as xylosyl donors and cholesterol as acceptor. Could also play a role in the catabolism of cytosolic sialyl free N-glycans. |
| Protein Name | Cytosolic Beta-GlucosidaseCytosolic Beta-Glucosidase-Like Protein 1Cytosolic GalactosylceramidaseCytosolic GlucosylceramidaseCytosolic GlycosylceramidaseCytosolic GcaseGlucosidase Beta Acid 3Glucosylceramidase Beta 3Klotho-Related ProteinKlrp |
| Database Links | Reactome: R-HSA-9840310 |
| Cellular Localisation | CytoplasmCytosol |
| Alternative Antibody Names | Anti-Cytosolic Beta-Glucosidase antibodyAnti-Cytosolic Beta-Glucosidase-Like Protein 1 antibodyAnti-Cytosolic Galactosylceramidase antibodyAnti-Cytosolic Glucosylceramidase antibodyAnti-Cytosolic Glycosylceramidase antibodyAnti-Cytosolic Gcase antibodyAnti-Glucosidase Beta Acid 3 antibodyAnti-Glucosylceramidase Beta 3 antibodyAnti-Klotho-Related Protein antibodyAnti-Klrp antibodyAnti-GBA3 antibodyAnti-CBG antibodyAnti-CBGL1 antibody |
Information sourced from Uniprot.org