| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-GBA3 (1-162) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IF/ICC 1:50-1:100 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
GBA3 |
| Gene ID: |
57733 |
| Uniprot ID: |
GBA3_HUMAN |
| Immunogen Region: |
1-162 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-162 of human GBA3 (NP_001121904.1). |
| Immunogen Sequence: |
MAFPAGFGWAAATAAYQVEG GWDADGKGPCVWDTFTHQGG ERVFKNQTGDVACGSYTLWE EDLKCIKQLGLTHYRFSLSW SRLLPDGTTGFINQKAIQLD KVNLQVYCAWSLLDNFEWNQ GYSSRFGLFHVDFEDPARPR VPYTSAKEYAKIIRNNGLEA HL |
| Tissue Specificity | Present in small intestine (at protein level). Expressed in liver, small intestine, colon, spleen and kidney. Down-regulated in renal cell carcinomas and hepatocellular carcinomas. |
| Post Translational Modifications | The N-terminus is blocked. |
| Function | Neutral cytosolic beta-glycosidase with a broad substrate specificity that could play a role in the catabolism of glycosylceramides. Has a significant glucosylceramidase activity in vitro. However, that activity is relatively low and its significance in vivo is not clear. Hydrolyzes galactosylceramides/GalCers, glucosylsphingosines/GlcSphs and galactosylsphingosines/GalSphs. However, the in vivo relevance of these activities is unclear. It can also hydrolyze a broad variety of dietary glycosides including phytoestrogens, flavonols, flavones, flavanones and cyanogens in vitro and could therefore play a role in the metabolism of xenobiotics. Possesses transxylosylase activity in vitro using xylosylated ceramides/XylCers (such as beta-D-xylosyl-(1<->1')-N-acylsphing-4-enine) as xylosyl donors and cholesterol as acceptor. Could also play a role in the catabolism of cytosolic sialyl free N-glycans. |
| Protein Name | Cytosolic Beta-GlucosidaseCytosolic Beta-Glucosidase-Like Protein 1Cytosolic GalactosylceramidaseCytosolic GlucosylceramidaseCytosolic GlycosylceramidaseCytosolic GcaseGlucosidase Beta Acid 3Glucosylceramidase Beta 3Klotho-Related ProteinKlrp |
| Database Links | Reactome: R-HSA-1660662 |
| Cellular Localisation | CytoplasmCytosol |
| Alternative Antibody Names | Anti-Cytosolic Beta-Glucosidase antibodyAnti-Cytosolic Beta-Glucosidase-Like Protein 1 antibodyAnti-Cytosolic Galactosylceramidase antibodyAnti-Cytosolic Glucosylceramidase antibodyAnti-Cytosolic Glycosylceramidase antibodyAnti-Cytosolic Gcase antibodyAnti-Glucosidase Beta Acid 3 antibodyAnti-Glucosylceramidase Beta 3 antibodyAnti-Klotho-Related Protein antibodyAnti-Klrp antibodyAnti-GBA3 antibodyAnti-CBG antibodyAnti-CBGL1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
