| Host: | Rabbit |
| Applications: | WB/IHC-P/IP/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IHC-P:1:50-1:200IP:0.5 Mu g-4 Mu g antibody for 200 Mu g-400 Mu g extracts of whole cellsELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | GATAD2B |
| Gene ID: | 57459 |
| Uniprot ID: | P66B_HUMAN |
| Immunogen Region: | 1-120 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-120 of human GATAD2B (NP_065750.1). |
| Immunogen Sequence: | MDRMTEDALRLNLLKRSLDP ADERDDVLAKRLKMEGHEAM ERLKMLALLKRKDLANLEVP HELPTKQDGSGVKGYEEKLN GNLRPHGDNRTAGRPGKENI NDEPVDMSARRSEPERGRLT |
| Tissue Specificity | Widely expressed. |
| Function | Transcriptional repressor. Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin. Enhances MBD2-mediated repression. Efficient repression requires the presence of GATAD2A. Targets MBD3 to discrete loci in the nucleus. May play a role in synapse development. |
| Protein Name | Transcriptional Repressor P66-BetaGata Zinc Finger Domain-Containing Protein 2bP66/P68 |
| Database Links | Reactome: R-HSA-3214815Reactome: R-HSA-427389Reactome: R-HSA-6804758Reactome: R-HSA-73762Reactome: R-HSA-8943724Reactome: R-HSA-9679191Reactome: R-HSA-9843940Reactome: R-HSA-9844594Reactome: R-HSA-9845323 |
| Cellular Localisation | Nucleus SpeckleNucleusChromosomeSpeckled Nuclear Localization Requires Both Cr1 And Cr2 RegionsLocalizes To Sites Of Dna Damage |
| Alternative Antibody Names | Anti-Transcriptional Repressor P66-Beta antibodyAnti-Gata Zinc Finger Domain-Containing Protein 2b antibodyAnti-P66/P68 antibodyAnti-GATAD2B antibodyAnti-KIAA1150 antibody |
Information sourced from Uniprot.org